Literature DB >> 6617735

Omeprazole provides protection against experimentally induced gastric mucosal lesions.

H Mattsson, K Andersson, H Larsson.   

Abstract

Omeprazole, given orally to rats, protects the gastric mucosa against various necrotizing agents, in doses (ED50 values 12-40 mumol/kg) which inhibit acid secretion. However, the protection is due to reduced acid secretion since omeprazole given intravenously in doses which completely inhibit acid secretion is not protective. The mechanism of the protective effect of omeprazole is unknown, but does not seem to be due to stimulation of the endogenous synthesis of prostaglandins since the effect was not blocked by indomethacin.

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Year:  1983        PMID： 6617735     DOI： 10.1016/0014-2999(83)90370-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Effects of NC-1300-B, a new benzimidazole derivative, on hog gastric H+, K+-ATPase, gastric acid secretion and HCl.ethanol-induced gastric lesions in rats.

Authors:  S Okabe; Y Akimoto; S Yamasaki; H Nagai
Journal:  Dig Dis Sci       Date:  1988-11       Impact factor: 3.199

2.  Abolition by omeprazole of aspirin induced gastric mucosal injury in man.

Authors:  T K Daneshmend; A G Stein; N K Bhaskar; C J Hawkey
Journal:  Gut       Date:  1990-05       Impact factor: 23.059

3.  Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanol-induced gastric lesions in rats.

Authors:  H Tanaka; M Nakagawa; K Takeuchi; S Okabe
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

4.  Acid-independent gastroprotective effects of lansoprazole in experimental mucosal injury.

Authors:  C Blandizzi; G Natale; G Gherardi; G Lazzeri; C Marveggio; R Colucci; D Carignani; M Del Tacca
Journal:  Dig Dis Sci       Date:  1999-10       Impact factor: 3.199

5.  Evaluation of putative cytoprotective properties of antiulcer drugs using quantitative histological techniques.

Authors:  P E O'Brien; G Frydman; R Holmes; C Malcontenti; D Phelan
Journal:  Dig Dis Sci       Date:  1990-09       Impact factor: 3.199

6.  Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice.

Authors:  T Azuma; M Dojyo; S Ito; Y Yamazaki; H Miyaji; Y Ito; H Suto; M Kuriyama; T Kato; Y Kohli
Journal:  Dig Dis Sci       Date:  1999-06       Impact factor: 3.199

Review 7.  Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome.

Authors:  S P Clissold; D M Campoli-Richards
Journal:  Drugs       Date:  1986-07       Impact factor: 9.546

8.  Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats.

Authors:  O Yamamoto; Y Okada; S Okabe
Journal:  Dig Dis Sci       Date:  1984-05       Impact factor: 3.199

9.  The role of thyrotropin-releasing hormone (TRH) in the pathogenesis of water-immersion stress in rats--inhibition of TRH release from the stomach by atropine, ranitidine or omeprazole.

Authors:  K Uchida; T Mitsuma; K Morise; H Kaneko; H Nagai; A Furusawa; K Nakada; Y Maeda
Journal:  Gastroenterol Jpn       Date:  1993-02

10.  PD-136,450: a CCK2 (gastrin) receptor antagonist with antisecretory, anxiolytic and antiulcer activity.

Authors:  S M A Bastaki; M Y Hasan; S I Chandranath; A Schmassmann; A Garner
Journal:  Mol Cell Biochem       Date:  2003-10       Impact factor: 3.396
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