Literature DB >> 2190865

Abolition by omeprazole of aspirin induced gastric mucosal injury in man.

T K Daneshmend1, A G Stein, N K Bhaskar, C J Hawkey.   

Abstract

This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to latin square. It was concluded that profound acid suppression can prevent aspirin induced gastric mucosal injury in normal subjects. This approach may prevent the development of peptic ulcers and their complications in patients taking aspirin and other non-steroidal anti-inflammatory drugs.

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Year:  1990        PMID： 2190865      PMCID： PMC1378564          DOI： 10.1136/gut.31.5.514

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  19 in total

1.  A procedure for measuring gastric bleeding caused by drugs.

Authors:  J N Hunt
Journal:  Dig Dis Sci       Date:  1979-07       Impact factor: 3.199

2.  Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.

Authors:  K Somerville; G Faulkner; M Langman
Journal:  Lancet       Date:  1986-03-01       Impact factor: 79.321

3.  Rising frequency of ulcer perforation in elderly people in the United Kingdom.

Authors:  R Walt; B Katschinski; R Logan; J Ashley; M Langman
Journal:  Lancet       Date:  1986-03-01       Impact factor: 79.321

4.  Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.

Authors:  D S Collier; J A Pain
Journal:  Gut       Date:  1985-04       Impact factor: 23.059

Review 5.  Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome.

Authors:  S P Clissold; D M Campoli-Richards
Journal:  Drugs       Date:  1986-07       Impact factor: 9.546

6.  Aspirin, paracetamol, and haematemesis and melaena.

Authors:  D Coggon; M J Langman; D Spiegelhalter
Journal:  Gut       Date:  1982-04       Impact factor: 23.059

7.  Omeprazole provides protection against experimentally induced gastric mucosal lesions.

Authors:  H Mattsson; K Andersson; H Larsson
Journal:  Eur J Pharmacol       Date:  1983-07-15       Impact factor: 4.432

8.  Effects of acid on the basal lamina of the rat stomach and duodenum.

Authors:  B A Black; G P Morris; J L Wallace
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1985

9.  Omeprazole inhibition of nocturnal gastric secretion in patients with duodenal ulcer.

Authors:  D J Hetzel; D J Shearman
Journal:  Br J Clin Pharmacol       Date:  1984-10       Impact factor: 4.335

10.  Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats.

Authors:  S J Konturek; T Brzozowski; T Radecki
Journal:  Digestion       Date:  1983       Impact factor: 3.216
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  19 in total

1.  Ranitidine, aspirin, food, and the stomach.

Authors:  A T Cole; S Brundell; N Hudson; A B Hawthorne; Y R Mahida; C J Hawkey
Journal:  BMJ       Date:  1992-02-29

2.  Primary prevention of adverse gastroduodenal effects from short-term use of non-steroidal anti-inflammatory drugs by omeprazole 20 mg in healthy subjects: a randomized, double-blind, placebo-controlled study.

Authors:  Jay C Desai; Shefali M Sanyal; Tyralee Goo; Ariel A Benson; Carol A Bodian; Kenneth M Miller; Lawrence B Cohen; James Aisenberg
Journal:  Dig Dis Sci       Date:  2008-01-26       Impact factor: 3.199

3.  Gastro-intestinal problems and concomitant medication in NSAID users: additional findings from a questionnaire-based survey in Italy.

Authors:  Maria Chiara Silvani; Domenico Motola; Elisabetta Poluzzi; Ambrogio Bottoni; Fabrizio De Ponti; Alberto Vaccheri; Nicola Montanaro
Journal:  Eur J Clin Pharmacol       Date:  2006-01-17       Impact factor: 2.953

Review 4.  [Risk of ulcer and its prophylaxis in therapy with non-steroidal antirheumatic drugs].

Authors:  L Köhler; W Mau; H Zeidler
Journal:  Med Klin (Munich)       Date:  1997-12-15

5.  Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.

Authors:  S Somasundaram; S Rafi; J Hayllar; G Sigthorsson; M Jacob; A B Price; A Macpherson; T Mahmod; D Scott; J M Wrigglesworth; I Bjarnason
Journal:  Gut       Date:  1997-09       Impact factor: 23.059

Review 6.  Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders.

Authors:  D McTavish; M M Buckley; R C Heel
Journal:  Drugs       Date:  1991-07       Impact factor: 9.546

7.  Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat.

Authors:  T Mahmud; S Somasundaram; G Sigthorsson; R J Simpson; S Rafi; R Foster; I A Tavares; A Roseth; A J Hutt; M Jacob; J Pacy; D L Scott; J M Wrigglesworth; I Bjarnason
Journal:  Gut       Date:  1998-12       Impact factor: 23.059

8.  Effect of proton pump inhibitors on gastric juice volume, gastric pH and gastric intramucosal pH in critically ill patients : a randomized, double-blind, placebo-controlled study.

Authors:  Olcay Gursoy; Dilek Memiş; Necdet Sut
Journal:  Clin Drug Investig       Date:  2008       Impact factor: 2.859

Review 9.  Rheumatoid arthritis in the aged. Incidence and optimal management.

Authors:  G Nesher; T L Moore
Journal:  Drugs Aging       Date:  1993 Nov-Dec       Impact factor: 3.923

10.  Nonsteroidal anti-inflammatory drugs. Proposed guidelines for monitoring toxicity.

Authors:  T M Bush; T L Shlotzhauer; K Imai
Journal:  West J Med       Date:  1991-07
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