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Literature DB >> 6617717

Reduction of phenytoin clearance caused by cimetidine.

G M Frigo, S Lecchini, M Caravaggi, G Gatti, M Tonini, L D'Angelo, E Perucca, A Crema.

Abstract

The effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two occasions, in the control state, and during concurrent treatment with cimetidine 1 200 mg/day for 6 days. A slight but statistically significant decrease both in the rate of elimination and total body clearance of phenytoin was observed during the administration of cimetidine. The effect is probably due to inhibition of metabolism.

Entities: Chemical

Mesh：

Substances：
Phenytoin
Cimetidine

Year: 1983 PMID： 6617717 DOI： 10.1007/bf00544030

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

10 in total

1. High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine.

Authors: W C Randolph; V L Osborne; S S Walkenstein; A P Intoccia
Journal: J Pharm Sci Date: 1977-08 Impact factor: 3.534

2. Micromethod for the determination of diphenylhydantoin in plasma and cerebrospinal fluid--a comparison between a gas chromatographic and a spectrophotometric method.

Authors: A Berlin; S Agurell; O Borgå; L Lund; F Sjöqvist
Journal: Scand J Clin Lab Invest Date: 1972-05 Impact factor: 1.713

3. Cimetidine interaction with phenytoin.

Authors: D J Hetzel; F Bochner; J F Hallpike; D J Shearman; C S Hann
Journal: Br Med J (Clin Res Ed) Date: 1981-05-09

Review 4. Drug interactions with cimetidine.

Authors: A Somogyi; R Gugler
Journal: Clin Pharmacokinet Date: 1982 Jan-Feb Impact factor: 6.447

5. Decreased clearance of phenytoin with cimetidine.

Authors: G J Algozzine; R B Stewart; P K Springer
Journal: Ann Intern Med Date: 1981-08 Impact factor: 25.391

Review 6. Pharmacokinetic interactions with antiepileptic drugs.

Authors: E Perucca
Journal: Clin Pharmacokinet Date: 1982 Jan-Feb Impact factor: 6.447

Review 7. Bioavailability of phenytoin: clinical pharmacokinetic and therapeutic implications.

Authors: P J Neuvonen
Journal: Clin Pharmacokinet Date: 1979 Mar-Apr Impact factor: 6.447

8. Effect of cimetidine on phenytoin serum levels.

Authors: R B Salem; B D Breland; S K Mishra; J E Jordan
Journal: Epilepsia Date: 1983-06 Impact factor: 5.864

9. Cimetidine-phenytoin interaction: effect on serum phenytoin concentration and antipyrine test.

Authors: P J Neuvonen; R A Tokola; M Kaste
Journal: Eur J Clin Pharmacol Date: 1981 Impact factor: 2.953

10. Interaction between phenytoin and valproic acid: plasma protein binding and metabolic effects.

Authors: E Perucca; S Hebdige; G M Frigo; G Gatti; S Lecchini; A Crema
Journal: Clin Pharmacol Ther Date: 1980-12 Impact factor: 6.875

10 in total

9 in total

Review 1. Clinical relevance of cimetidine drug interactions.

Authors: A F Shinn
Journal: Drug Saf Date: 1992 Jul-Aug Impact factor: 5.606

Review 2. Treatment of concomitant illnesses in patients receiving anticonvulsants: drug interactions of clinical significance.

Authors: P Loiseau
Journal: Drug Saf Date: 1998-12 Impact factor: 5.606

Reduction of phenytoin clearance caused by cimetidine.

1. High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine.

2. Micromethod for the determination of diphenylhydantoin in plasma and cerebrospinal fluid--a comparison between a gas chromatographic and a spectrophotometric method.

3. Cimetidine interaction with phenytoin.

Review 4. Drug interactions with cimetidine.

5. Decreased clearance of phenytoin with cimetidine.

Review 6. Pharmacokinetic interactions with antiepileptic drugs.

Review 7. Bioavailability of phenytoin: clinical pharmacokinetic and therapeutic implications.

8. Effect of cimetidine on phenytoin serum levels.

9. Cimetidine-phenytoin interaction: effect on serum phenytoin concentration and antipyrine test.

10. Interaction between phenytoin and valproic acid: plasma protein binding and metabolic effects.

Review 1. Clinical relevance of cimetidine drug interactions.

Review 2. Treatment of concomitant illnesses in patients receiving anticonvulsants: drug interactions of clinical significance.

Review 3. Pharmacokinetic drug interactions with phenytoin (Part II).

Review 4. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Review 5. Differential kinetics of phenytoin in elderly patients.

Review 6. Ranitidine versus cimetidine. A comparison of their potential to cause clinically important drug interactions.

7. A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow.

Review 8. Pharmacokinetic interactions of cimetidine 1987.

Review 9. Adverse reactions and interactions with H2-receptor antagonists.