| Literature DB >> 6615562 |
S M Wahl, R L Wilder, I M Katona, L M Wahl, J B Allen, I Scher, J L Decker.
Abstract
In order to study the clinical and immunologic effects of a brief course of leukapheresis, 14 patients with clinically similar rheumatoid arthritis were segregated into 2 subgroups. Group A (7 patients) had subnormal lymphocyte tritiated thymidine incorporation to soluble antigens. After a brief course of leukapheresis, 6 of these 7 patients demonstrated substantial clinical improvement associated with significantly enhanced lymphocyte tritiated thymidine incorporation to soluble antigens. In contrast, none of the 7 patients in group B (normal immune functions) demonstrated similar changes in articular indices or lymphocyte proliferation. Thus, clinical improvement induced in a subset of rheumatoid arthritis patients appears to reflect modulation of function, and not simply immunosuppression.Entities:
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Year: 1983 PMID： 6615562 DOI： 10.1002/art.1780260904
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591