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Literature DB >> 6614895

Effect of beta-lactam antibiotics on migration and bactericidal activity of human phagocytes.

A Fietta, F Sacchi, C Bersani, F Grassi, P Mangiarotti, G G Grassi.

Abstract

The effect of beta-lactam antibiotics upon some functions of human phagocytes was examined. Penicillins (carbenicillin and piperacillin), thienamycin, and cephalosporins (cefotetan, ceftazidime, and moxalactam) had no effect on either the random or directional migration or on the bactericidal activity of neutrophils and monocytes against Staphylococcus aureus. On the contrary, cefoperazone at therapeutic levels was shown to inhibit neutrophil chemotaxis.

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Year: 1983 PMID： 6614895 PMCID： PMC185008 DOI： 10.1128/AAC.23.6.930

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

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Authors: G T Keusch; S D Douglas; K Ugurbil
Journal: J Infect Dis Date: 1975-05 Impact factor: 5.226

2. Defective neutrophil chemotactic responses in patients with recurrent episodes of otitis media and chronic diarrhea.

Authors: H R Hill; L S Book; V G Hemming; J J Herbst
Journal: Am J Dis Child Date: 1977-04

3. Use and results of neutrophil function testing in pediatric immunology.

Authors: A G Siccardi; A G Ugazio; F Sacchi; S D Jayakar
Journal: Adv Exp Med Biol Date: 1982 Impact factor: 2.622

4. Direct and indirect effects of antibiotics on granulocyte activity.

Authors: H Gnarpe; J Belsheim
Journal: J Antimicrob Chemother Date: 1981-11 Impact factor: 5.790

5. Protection of staphylococci ingested by macrophages from the bactericidal action of rifampin.

Authors: E L Pesanti
Journal: Antimicrob Agents Chemother Date: 1980-07 Impact factor: 5.191

6. Requirement of extracellular complement and immunoglobulin for intracellular killing of micro-organisms by human monocytes.

Authors: P C Leijh; M T van den Barselaar; T L van Zwet; M R Daha; R van Furth
Journal: J Clin Invest Date: 1979-04 Impact factor: 14.808

7. Antibiotic-host defence interactions in vitro and in vivo.

Authors: A Forsgren; G Banck; H Beckman; A Bellahsène
Journal: Scand J Infect Dis Suppl Date: 1980

8. Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function.

Authors: W D Welch; D Davis; L D Thrupp
Journal: Antimicrob Agents Chemother Date: 1981-07 Impact factor: 5.191