Literature DB >> 6610687

Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.

P H Steenbergh, J W Höppener, J Zandberg, W J Van de Ven, H S Jansz, C J Lips.   

Abstract

Nucleotide sequence analysis of part of the human calcitonin (hCT) gene revealed the presence of a region with 90% homology to the region in the corresponding rat gene encoding calcitonin gene related peptide (CGRP). Analysis of RNA isolated from human medullary thyroid carcinoma (MTC) indicated that in these tumors mRNA hybridizing to hCT specific probe, mRNA hybridizing to hCGRP specific probe and larger RNA species hybridizing to both hCT and hCGRP probes occur. These results suggest that alternative splicing of the primary transcripts of the human CT gene may result in hCT or hCGRP mRNA.

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Year:  1984        PMID： 6610687     DOI： 10.1210/jcem-59-2-358

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  19 in total

1.  Human calcitonin gene regulation by helix-loop-helix recognition sequences.

Authors:  D W Ball; D Compton; B D Nelkin; S B Baylin; A de Bustros
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

2.  Identification of a new calcitonin gene in the salmon Oncorhynchus gorbuscha.

Authors:  H Jansz; K Martial; J Zandberg; G Milhaud; A A Benson; A Julienne; M S Moukhtar; M Cressent
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

3.  Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma.

Authors:  A de Bustros; R Y Lee; D Compton; T Y Tsong; S B Baylin; B D Nelkin
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

4.  Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary.

Authors:  F A Tschopp; H Henke; J B Petermann; P H Tobler; R Janzer; T Hökfelt; J M Lundberg; C Cuello; J A Fischer
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

5.  The second human calcitonin/CGRP gene is located on chromosome 11.

Authors:  J W Höppener; P H Steenbergh; J Zandberg; A H Geurts van Kessel; S B Baylin; B D Nelkin; H S Jansz; C J Lips
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

6.  Synthesis of an analog of human calcitonin gene related peptide, [Asu]-h-CGRP.

Authors:  T Noda; K Morita; T Uzawa; H Kinoshita; M Hori
Journal:  Experientia       Date:  1987-08-15

7.  Model for tissue specific Calcitonin/CGRP-I RNA processing from in vitro experiments.

Authors:  R A Bovenberg; G J Adema; H S Jansz; P D Baas
Journal:  Nucleic Acids Res       Date:  1988-08-25       Impact factor: 16.971

8.  Human alpha-calcitonin gene-related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature.

Authors:  I Marshall; S J Al-Kazwini; J J Holman; R K Craig
Journal:  Br J Clin Pharmacol       Date:  1988-12       Impact factor: 4.335

9.  Structural characterization of a high-molecular-mass form of calcitonin [procalcitonin-(60-116)-peptide] and its corresponding N-terminal flanking peptide [procalcitonin-(1-57)-peptide] in a human medullary thyroid carcinoma.

Authors:  J M Conlon; L Grimelius; L Thim
Journal:  Biochem J       Date:  1988-11-15       Impact factor: 3.857

10.  The calcitonin gene is expressed in salmon gills.

Authors:  K Martial; L Maubras; J Taboulet; A Jullienne; M Berry; G Milhaud; A A Benson; M S Moukhtar; M Cressent
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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