Literature DB >> 6609075

Tumor detection with carbon-11-labelled amino acids.

K Kubota, K Yamada, H Fukada, S Endo, M Ito, Y Abe, T Yamaguchi, T Fujiwara, T Sato, K Ito.   

Abstract

A comparative study of tumor detection with ten 11C-labeled amino acids including four newly synthesized amino acids was carried out to find the most valuable 11C-labeled amino acid for the diagnosis of cancer. 11C-L-methionine showed the highest uptake by the experimental rat hepatoma AH109A (2.7% administered dose/g at 20 min, tumor to blood ratio; 11.4). The second highest uptake was of 11C-aminocyclopentane-carboxylic acid (ACPC). The newly synthesized 11C-DL-methyl-ACPC characteristically showed higher accumulation in tumor than in liver and the tumor to liver ratio reached 3.0 at 60 min after injection. It is suggested that 11C-L-methionine and 11C-DL-methyl-ACPC are useful amino acids for the diagnosis of cancer using positron emission tomography.

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Year:  1984        PMID： 6609075     DOI： 10.1007/bf00253516

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  11 in total

1.  Autoradiographic studies of the distribution of 1-aminocyclopentane carboxylic acid in normal and cancerous mice.

Authors:  L BERLINGUET; N BEGIN; L M BABINEAU
Journal:  Can J Biochem Physiol       Date:  1962-08

2.  The uptake of a variety of amino acids into nuclear proteins of tumors and other tissues.

Authors:  H BUSCH; J R DAVIS; G R HONIG; D C ANDERSON; P V NAIR; W L NYHAN
Journal:  Cancer Res       Date:  1959-11       Impact factor: 12.701

3.  Quantitative scanning of osteogenic sarcoma with nitrogen-13-labeled L-glutamate.

Authors:  A S Gelbard; R S Benua; J S Laughlin; G Rosen; R E Reiman; J M McDonald
Journal:  J Nucl Med       Date:  1979-07       Impact factor: 10.057

4.  Tumor detection with 1-aminocyclopentane and 1-aminocyclobutane C-11-carboxylic acid using positron emission computerized tomography.

Authors:  K F Hübner; S Krauss; L C Washburn; W D Gibbs; E C Holloway
Journal:  Clin Nucl Med       Date:  1981-06       Impact factor: 7.794

5.  Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors.

Authors:  A M Markoe; V R Risch; N D Heindel; J Emrich; W Lippincott; T Honda; L W Brady
Journal:  J Nucl Med       Date:  1979-07       Impact factor: 10.057

6.  Labelling and metabolism of methionine-methyl-11 C.

Authors:  D Comar; J Cartron; M Maziere; C Marazano
Journal:  Eur J Nucl Med       Date:  1976

7.  [11C]methionine pancreatic scanning with positron emission computed tomography.

Authors:  A Syrota; D Comar; M Cerf; D Plummer; M Mazière; C Kellershohn
Journal:  J Nucl Med       Date:  1979-07       Impact factor: 10.057

8.  Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication.

Authors:  R E Reiman; R S Benua; A S Gelbard; J C Allen; J J Vomero; J S Laughlin
Journal:  J Nucl Med       Date:  1982-08       Impact factor: 10.057

9.  The role of positron emission tomography in the detection of pancreatic disease.

Authors:  A Syrota; N Duquesnoy; A Paraf; C Kellershohn
Journal:  Radiology       Date:  1982-04       Impact factor: 11.105

10.  Synthesis and body distribution of alpha-aminoisobutyric acid-L-11C in normal and prostate cancer-bearing rat after chemotherapy.

Authors:  U Dunzendorfer; B Schmall; R E Bigler; P B Zanzonico; P S Conti; J R Dahl; E Kleinert; W F Whitmore
Journal:  Eur J Nucl Med       Date:  1981
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  12 in total

Review 1.  Newer positron emission tomography radiopharmaceuticals for radiotherapy planning: an overview.

Authors:  Punit Sharma; Anirban Mukherjee
Journal:  Ann Transl Med       Date:  2016-02

2.  Non selective transport of [11C-methyl]-L-and D-methionine into a malignant glioma.

Authors:  O Schober; C Duden; G J Meyer; J A Müller; H Hundeshagen
Journal:  Eur J Nucl Med       Date:  1987

3.  Evaluation of D-isomers of O-18F-fluoromethyl, O-18F-fluoroethyl and O-18F-fluoropropyl tyrosine as tumour imaging agents in mice.

Authors:  Hideo Tsukada; Kengo Sato; Dai Fukumoto; Takeharu Kakiuchi
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-05-13       Impact factor: 9.236

4.  6-[18F]fluoro-L-DOPA uptake in the rat pancreas is dependent on the tracer metabolism.

Authors:  Teemu Kalliokoski; Johanna Tuomela; Laura Haavisto; Sarita Forsback; Anniina Snellman; Semi Helin; Tove J Grönroos; Olof Solin; Merja Haaparanta-Solin
Journal:  Mol Imaging Biol       Date:  2013-11-12       Impact factor: 3.488

5.  Uptake of 11C-L- and D-methionine in brain tumors.

Authors:  G J Meyer; O Schober; H Hundeshagen
Journal:  Eur J Nucl Med       Date:  1985

6.  Uptake kinetics of 14C L-leucine and 14C L- and 14C D-methionine in rat brain and incorporation into protein.

Authors:  L Lauenstein; G J Meyer; K F Sewing; O Schober; H Hundeshagen
Journal:  Neurosurg Rev       Date:  1987       Impact factor: 3.042

7.  Potential radiopharmaceuticals for the detection of ocular melanoma. Part III. A study with 14C and 11C labelled tyrosine and dihydroxyphenylalanine.

Authors:  A van Langevelde; H D van der Molen; J G Journée-de Korver; A M Paans; E K Pauwels; W Vaalburg
Journal:  Eur J Nucl Med       Date:  1988

8.  Body distribution of C-methionine and FDG in rat measured by microPET.

Authors:  Svorad Stolc; Lucia Jakubíková; Ivica Kukurová
Journal:  Interdiscip Toxicol       Date:  2011-03

9.  PET Use in Cancer Diagnosis, Treatment, and Prognosis.

Authors:  Naresh Damuka; Meghana Dodda; Kiran Kumar Solingapuram Sai
Journal:  Methods Mol Biol       Date:  2022

10.  Kinetic evaluation of 11C-1-aminocyclopentane carboxylic acid in rabbits bearing VX-2 tumors using positron emission tomography.

Authors:  T Fujiwara; T Matsuzawa; H Kawai; R Kawashima; M Itoh; S Watanuki; T Takahashi; R Iwata; T Ido
Journal:  Jpn J Cancer Res       Date:  1989-12
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