Literature DB >> 6607151

Prostaglandins cause an increase in serum acute-phase proteins in man, which is diminished in systemic sclerosis.

J T Whicher, A M Bell, M F Martin, L A Marshall, P A Dieppe.   

Abstract

The prostaglandin E1 increases the plasma concentration of acute-phase proteins in man and decreases the concentration of certain carrier proteins. This response is greatly diminished in patients with systemic sclerosis, a chronic inflammatory disease leading to fibrosis. These findings pose new questions about the mediation of the acute-phase response and its role in controlling the inflammatory process.

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Year:  1984        PMID： 6607151     DOI： 10.1042/cs0660165

Source DB:  PubMed          Journal:  Clin Sci (Lond)        ISSN： 0143-5221            Impact factor:   6.124


  3 in total

1.  Defective production of leucocytic endogenous mediator (interleukin 1) by peripheral blood leucocytes of patients with systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease.

Authors:  J T Whicher; A M Gilbert; C Westacott; C Hutton; P A Dieppe
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330

2.  Acute phase response of serum amyloid A protein and C reactive protein to the common cold and influenza.

Authors:  J T Whicher; R E Chambers; J Higginson; L Nashef; P G Higgins
Journal:  J Clin Pathol       Date:  1985-03       Impact factor: 3.411

3.  Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.

Authors:  C W Hutton; A J Collins; R E Chambers; J Whicher; P A Dieppe
Journal:  Ann Rheum Dis       Date:  1985-08       Impact factor: 19.103
  3 in total

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