Literature DB >> 3491701

Defective production of leucocytic endogenous mediator (interleukin 1) by peripheral blood leucocytes of patients with systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease.

J T Whicher, A M Gilbert, C Westacott, C Hutton, P A Dieppe.   

Abstract

Leucocytic endogenous mediator is one of the activities ascribed to the cytokine or family of cytokines known as interleukin 1. In this study we have examined the ability of circulating blood leucocytes from patients with rheumatic diseases to produce this mediator in vitro. Leucocytic endogenous mediator production was found to be significantly decreased below normal values (mean 107 units, s.e.m. +/- 25) in systemic sclerosis (-6 units +/- 18), systemic lupus erythematosus (-25 units +/- 13), rheumatoid arthritis (-3 units +/- 13) and mixed connective tissue disease (-4 units +/- 40). A control group of ill patients with cancer produced 57 units +/- 8.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3491701      PMCID： PMC1542270     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  35 in total

1.  Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes.

Authors:  S B Mizel; J J Oppenheim; D L Rosenstreich
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

Review 2.  Leukocytic endogenous mediator.

Authors:  R F Kampschmidt
Journal:  J Reticuloendothel Soc       Date:  1978-04

3.  Cellular infiltrates in scleroderma skin.

Authors:  R Fleischmajer; J S Perlish; J R Reeves
Journal:  Arthritis Rheum       Date:  1977-05

4.  Electroimmuno assay.

Authors:  C B Laurell
Journal:  Scand J Clin Lab Invest Suppl       Date:  1972

5.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

6.  Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P388D.

Authors:  S B Mizel; D L Rosenstreich; J J Oppenheim
Journal:  Cell Immunol       Date:  1978-09-15       Impact factor: 4.868

7.  Effect of human monocyte pyrogen on plasma iron, plasma zinc, and blood neutrophils in rabbits and rats.

Authors:  R F Kampschmidt; L A Pulliam
Journal:  Proc Soc Exp Biol Med       Date:  1978-05

8.  Purification and properties of human B cell-activating factor.

Authors:  D D Wood
Journal:  J Immunol       Date:  1979-11       Impact factor: 5.422

9.  Interleukin-1 production by mononuclear cells from patients with scleroderma.

Authors:  C I Sandborg; M A Berman; B S Andrews; G J Friou
Journal:  Clin Exp Immunol       Date:  1985-05       Impact factor: 4.330

10.  Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide.

Authors:  C F Nathan; L H Brukner; S C Silverstein; Z A Cohn
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307
View more
  9 in total

1.  Anti-DNA idiotype- and anti-idiotype-specific T cell responses in patients with systemic lupus erythematosus and their first-degree relatives.

Authors:  S Mendlovic; R Segal; Y Shoenfeld; E Mozes
Journal:  Clin Exp Immunol       Date:  1990-12       Impact factor: 4.330

2.  Responsiveness of systemic lupus erythematosus T cells to signals provided through LCA T200 (CD45) and T1 (CD5) antigens.

Authors:  J Martorell; J Font; I Rojo; R Vilella; M Ingelmo; J Vives
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

3.  Association of interleukin 1 family with systemic sclerosis.

Authors:  Li Zhang; Jun-Wei Yan; Yu-Jie Wang; Ya-Nan Wan; Bing-Xiang Wang; Jin-Hui Tao; Bing Chen; Bao-Zhu Li; Guo-Jun Yang; Jing Wang
Journal:  Inflammation       Date:  2014-08       Impact factor: 4.092

Review 4.  The role of cytokines in the immunopathogenesis of lupus.

Authors:  B S Handwerger; V Rus; L da Silva; C S Via
Journal:  Springer Semin Immunopathol       Date:  1994

5.  Monocyte activation in early onset rheumatoid arthritis.

Authors:  I Fujii; M Shingu; M Nobunaga
Journal:  Ann Rheum Dis       Date:  1990-07       Impact factor: 19.103

Review 6.  Anaemia in rheumatoid arthritis: pathogenesis, diagnosis and treatment.

Authors:  G Vreugdenhil; A J Swaak
Journal:  Rheumatol Int       Date:  1990       Impact factor: 2.631

7.  Interleukin-1-production by monocytes from patients with systemic lupus erythematosus.

Authors:  S Sierakowski; E J Kucharz; R W Lightfoot; J S Goodwin
Journal:  Clin Rheumatol       Date:  1987-09       Impact factor: 2.980

Review 8.  Cytokines and autoimmunity.

Authors:  M G Cavallo; P Pozzilli; R Thorpe
Journal:  Clin Exp Immunol       Date:  1994-04       Impact factor: 4.330

9.  Production of intracellular and extracellular interleukin-1 alpha and interleukin-1 beta by peripheral blood monocytes from patients with connective tissue diseases.

Authors:  S Aotsuka; K Nakamura; T Nakano; M Kawakami; M Goto; M Okawa-Takatsuji; M Kinoshita; R Yokohari
Journal:  Ann Rheum Dis       Date:  1991-01       Impact factor: 19.103
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.