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Literature DB >> 6607037

Cysteine proteinase inhibitors in psoriatic epidermis.

V K Hopsu-Havu, I A Joronen, M Järvinen, A Rinne.

Abstract

Human psoriatic epidermis and scales were demonstrated to contain two antigenically separate cysteine proteinase inhibitors, one acidic with an isoelectric point of 4.7-5.0 (ACPI) and one neutral with an isoelectric point of 6.0-6.5 (NCPI), while normal epidermis contains only ACPI. The total papain (cysteine proteinase) inhibiting activity of the psoriatic epidermis as calculated per mg protein was higher than that in normal epidermis. Both ACPI and NCPI were localized immunocytochemically, mainly in the highest spinous cell layers with less activity in the parakeratotic cells and lower layers of spinous cells. Basal cells were essentially negative.

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Year: 1983 PMID： 6607037 DOI： 10.1007/bf00417202

Source DB: PubMed Journal: Arch Dermatol Res ISSN： 0340-3696 Impact factor: 3.017

20 in total

1. alpha-N-benzoylarginine-2-naphthylamide hydrolase (cathepsin B1 ?) from rat skin. II. Purification of the enzyme and demonstration of two inhibitors in the skin.

Authors: M Järvinen; V K Hopsu-Havu
Journal: Acta Chem Scand B Date: 1975

2. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

3. Purification and some characteristics of two human serum proteins inhibiting papain and other thiol proteinases.

Authors: M Järvinen
Journal: FEBS Lett Date: 1979-12-15 Impact factor: 4.124

4. Characterization of a chemotactic and cytotoxic proteinase from human skin.

Authors: V B Hatcher; G S Lazarus; N Levine; P G Burk; F J Yost
Journal: Biochim Biophys Acta Date: 1977-07-08

5. Inhibition studies of an intracellular inhibitor on thiol proteinases.

Authors: M Kopitar; J Brzin; T Zvonar; P Locnikar; I Kregar; V Turk
Journal: FEBS Lett Date: 1978-07-15 Impact factor: 4.124

6. Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis.

Authors: G S Lazarus; F J Yost; C A Thomas
Journal: Science Date: 1977-12-16 Impact factor: 47.728

7. Purification and properties of two protease inhibitors from rat skin inhibiting papain and other SH-proteases.

Authors: M Järvinen
Journal: Acta Chem Scand B Date: 1976

8. A protein reminiscent of the epidermal SH-protease inhibitor occurs in squamous epithelia of man and rat.

Authors: A Rinne; M Järvinen; O Räsänen
Journal: Acta Histochem Date: 1978 Impact factor: 2.479

9. The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.

Authors: A J Barrett; P M Starkey
Journal: Biochem J Date: 1973-08 Impact factor: 3.857

10. Human spleen cysteineproteinase inhibitor. Purification, fractionation into isoelectric variants and some properties of the variants.

Authors: M Järvinen; A Rinne
Journal: Biochim Biophys Acta Date: 1982-11-09

6 in total

1. Purification and characterization of a cystatin-type cysteine proteinase inhibitor in the human hair shaft.

Authors: H Tsushima; A Ueki; H Mine; N Nakajima; H Sumi; V K Hopsu-Havu
Journal: Arch Dermatol Res Date: 1992 Impact factor: 3.017

2. Isolation and amino acid sequence of a cystatin-type cysteine proteinase inhibitor from bovine hoof.

Authors: H Tsushima; K Higashiyama; H Mine
Journal: Arch Dermatol Res Date: 1996-07 Impact factor: 3.017

3. Rhabdovirus-induced apoptosis in a fish cell line is inhibited by a human endogenous acid cysteine proteinase inhibitor.

Authors: H V Björklund; T R Johansson; A Rinne
Journal: J Virol Date: 1997-07 Impact factor: 5.103