Literature DB >> 660456

Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients.

R D Schoenwald, R L Ward.   

Abstract

Permeability rates were determined across excised rabbit corneas for 11 steroids. Permeability coefficients for each steroid were calculated, and their logarithms were plotted against their respective log octanol-water partition coefficients. A parabolic relationship resulted, with an optimum log permeability and coefficient observed at a log Po of 2.9. From these experimental results, an improvement in ophthalmic bioavailability of dexamethasone acetate as compared to dexamethasone is predicted and correlates with literature results.

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Year:  1978        PMID： 660456     DOI： 10.1002/jps.2600670614

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  19 in total

1.  Spinal disposition and meningeal permeability of local anesthetics.

Authors:  Rozenn Clément; Jean-Marc Malinovsky; Patrice Hildgen; Gilles Dollo; Jean Pierre Estèbe; François Chevanne; Roger Le Verge; Pascal Le Corre
Journal:  Pharm Res       Date:  2004-04       Impact factor: 4.200

2.  Prediction of the corneal permeability of drug-like compounds.

Authors:  Heidi Kidron; Kati-Sisko Vellonen; Eva M del Amo; Anita Tissari; Arto Urtti
Journal:  Pharm Res       Date:  2010-04-13       Impact factor: 4.200

Review 3.  Ocular drug delivery. Pharmacokinetic considerations.

Authors:  R D Schoenwald
Journal:  Clin Pharmacokinet       Date:  1990-04       Impact factor: 6.447

4.  Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow.

Authors:  Rajendra S Kadam; Gajanan Jadhav; Miller Ogidigben; Uday B Kompella
Journal:  Drug Metab Dispos       Date:  2011-06-14       Impact factor: 3.922

5.  Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus.

Authors:  O Camber; C Rehbinder; T Nikkila; P Edman
Journal:  Acta Vet Scand       Date:  1987       Impact factor: 1.695

6.  Pharmacokinetic transfer functions and generalized clearances.

Authors:  R A Siegel
Journal:  J Pharmacokinet Biopharm       Date:  1986-10

Review 7.  Ocular delivery of proteins and peptides: Challenges and novel formulation approaches.

Authors:  Abhirup Mandal; Dhananjay Pal; Vibhuti Agrahari; Hoang My Trinh; Mary Joseph; Ashim K Mitra
Journal:  Adv Drug Deliv Rev       Date:  2018-01-13       Impact factor: 15.470

8.  Ocular pharmacokinetic models of clonidine-3H hydrochloride.

Authors:  C H Chiang; R D Schoenwald
Journal:  J Pharmacokinet Biopharm       Date:  1986-04

9.  [Transcorneal-paracorneal penetration route for topical application of drugs to the eyt. Mycophenolate mofetil as a model substance].

Authors:  E Bertelmann; S Knapp; P Rieck; S Keipert; C Hartmann; U Pleyer
Journal:  Ophthalmologe       Date:  2003-09       Impact factor: 1.059

10.  Effect of 2-hydroxypropyl-beta-cyclodextrin on the ocular absorption of dexamethasone and dexamethasone acetate.

Authors:  A Usayapant; A H Karara; M M Narurkar
Journal:  Pharm Res       Date:  1991-12       Impact factor: 4.200
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