| Literature DB >> 29339145 |
Abhirup Mandal1, Dhananjay Pal1, Vibhuti Agrahari1, Hoang My Trinh1, Mary Joseph1, Ashim K Mitra2.
Abstract
The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches. Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large size, poor permeation and susceptibility to degradation. A wide range of advanced drug delivery systems including polymeric controlled release systems, cell-based delivery and nanowafers are being exploited to overcome the challenges of frequent administration to ocular tissues. The next generation systems integrated with new delivery technologies are anticipated to generate improved efficacy and safety through the expansion of the therapeutic target space. This review will highlight recent advances in formulation and delivery strategies of protein and peptide based biopharmaceuticals. We will also describe the current state of proteins and peptides based ocular therapy and future therapeutic opportunities.Entities:
Keywords: AMD; Barriers; Biologics; Biopharmaceuticals; Controlled release; Drug delivery; Eye; Macromolecules; Targeting
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Year: 2018 PMID： 29339145 PMCID： PMC5995646 DOI： 10.1016/j.addr.2018.01.008
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470