Literature DB >> 660455

Extraction of daunorubicin and doxorubicin and their hydroxyl metabolites: self-association in aqueous solution.

S Eksborg.   

Abstract

The extraction of daunorubicin and doxorubicin and their hydroxyl metabolites daunorubicinol and doxorubicinol was studied using chloroform-1-pentanol (9:1) as the organic phase. Because of differences in acid dissociation constants, the pH for optimum extraction varied from 8.0 to 8.6 for the different compounds. Self-association in the aqueous phase significantly influenced the distribution ratio. Constants for the formation of dimers and tetramers in aqueous solutions were about 10(4.5) and 10(12), respectively.

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Year:  1978        PMID： 660455     DOI： 10.1002/jps.2600670613

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  11 in total

Review 1.  Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. II. Assay methods, adriamycin and the other antitumour antibiotics.

Authors:  A G Bosanquet
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

2.  Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads.

Authors:  Luo Gu; Ji-Ho Park; Kim H Duong; Erkki Ruoslahti; Michael J Sailor
Journal:  Small       Date:  2010-11-22       Impact factor: 13.281

3.  The interaction of Fe(III), adriamycin and daunomycin with nucleotides and DNA and their effects on cell growth of fibroblasts (NIH-3T3).

Authors:  I Di Liegro; A Cestelli; B F Matzanke; E Bill; A X Trautwein
Journal:  Biometals       Date:  1996-04       Impact factor: 2.949

4.  Alpha-DNA. IV: Alpha-anomeric and beta-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding.

Authors:  C Gautier; F Morvan; B Rayner; T Huynh-Dinh; J Igolen; J L Imbach; C Paoletti; J Paoletti
Journal:  Nucleic Acids Res       Date:  1987-08-25       Impact factor: 16.971

5.  Effect of modification of the physicochemical properties of ICAM-1-derived peptides on internalization and intracellular distribution in the human leukemic cell line HL-60.

Authors:  Sumit Majumdar; Bimo A Tejo; Ahmed H Badawi; David Moore; Jeffrey P Krise; Teruna J Siahaan
Journal:  Mol Pharm       Date:  2009 Mar-Apr       Impact factor: 4.939

6.  Pharmacokinetics of doxorubicin and its metabolite doxorubicinol in rabbits with induced acid and alkaline urine.

Authors:  P B Johansen; S E Jensen; S N Rasmussen; M Dalmark
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

Review 7.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

8.  Protein binding of anthraquinone glycosides, with special reference to adriamycin.

Authors:  S Eksborg; H Ehrsson; B Ekqvist
Journal:  Cancer Chemother Pharmacol       Date:  1982-12       Impact factor: 3.333

9.  Label-free isolation of a prostate cancer cell among blood cells and the single-cell measurement of drug accumulation using an integrated microfluidic chip.

Authors:  A Khamenehfar; T V Beischlag; P J Russell; M T P Ling; C Nelson; P C H Li
Journal:  Biomicrofluidics       Date:  2015-11-12       Impact factor: 2.800

10.  Possible intermediates in the action of adriamycin--a pulse radiolysis study.

Authors:  E J Land; T Mukherjee; A J Swallow; J M Bruce
Journal:  Br J Cancer       Date:  1985-04       Impact factor: 7.640
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