Literature DB >> 6603257

Intrathecal vincristine. Report of a fatal case despite CNS washout.

W G Gaidys, J D Dickerman, C L Walters, P C Young.   

Abstract

The clinical course of a two-year-old girl with acute lymphocytic leukemia (ALL) who inadvertently received intrathecal vincristine is presented. Despite aggressive treatment with parenteral folinic acid and extensive central nervous system washout, the outcome was fatal. The pharmacologic aspects of vincristine and folinic acid that may explain why treatment was unsuccessful, are reviewed.

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Year:  1983        PMID： 6603257     DOI： 10.1002/1097-0142(19830901)52:5<799::aid-cncr2820520508>3.0.co;2-z

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  4 in total

1.  Accidental iatrogenic intoxications by cytotoxic drugs: error analysis and practical preventive strategies.

Authors:  B Zernikow; E Michel; G Fleischhack; U Bode
Journal:  Drug Saf       Date:  1999-07       Impact factor: 5.606

Review 2.  Intrathecal vincristine: a fatal chemotherapeutic error with devastating central nervous system effects.

Authors:  P G Bain; P L Lantos; V Djurovic; I West
Journal:  J Neurol       Date:  1991-07       Impact factor: 4.849

3.  Effects of chemotherapeutics on organotypic corticostriatal slice cultures identified by a panel of fluorescent and immunohistochemical markers.

Authors:  Annette Nørregaard; Stine Skov Jensen; Jesper Kolenda; Charlotte Aaberg-Jessen; Karina Garnier Christensen; Poul Henning Jensen; Henrik Daa Schrøder; Bjarne Winther Kristensen
Journal:  Neurotox Res       Date:  2011-12-28       Impact factor: 3.911

Review 4.  Clinical management of cytotoxic drug overdose.

Authors:  L L Thomas; M J Mertens; A E von dem Borne; C J van Boxtel; C H Veenhof; E P Veies
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Jul-Aug
  4 in total

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