Literature DB >> 3054425

Clinical management of cytotoxic drug overdose.

L L Thomas1, M J Mertens, A E von dem Borne, C J van Boxtel, C H Veenhof, E P Veies.   

Abstract

In this article the pharmacological management of accidental drug overdose is discussed, with various treatments for overdose proposed, as supported by clinical facts and speculation. Current knowledge is outlined concerning dacarbazine, nitrosourea compounds, melphalan, procarbazine, cyclophosphamide, VP-16.213, l-asparaginase (colaspase), 6-mercaptopurine, mustine (nitrogen mustard), intravenous or intrathecal methotrexate (amethopterin), cytarabine (cytosine arabinoside), fluorouracil and bleomycin.

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Year:  1988        PMID: 3054425     DOI: 10.1007/bf03259938

Source DB:  PubMed          Journal:  Med Toxicol Adverse Drug Exp        ISSN: 0113-5244


  88 in total

1.  Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.

Authors:  G J Goldenberg; C L Vanstone; L G Israels; D Iise; I Bihler
Journal:  Cancer Res       Date:  1970-09       Impact factor: 12.701

2.  Clinical pharmacologic studies of L-asparaginase.

Authors:  D H Ho; B Thetford; C J Carter; E Frei
Journal:  Clin Pharmacol Ther       Date:  1970 May-Jun       Impact factor: 6.875

3.  Transport of nitrogen mustard on the transport-carrier for choline in L5178Y lymphoblasts.

Authors:  G J Goldenberg; C L Vanstone; I Bihler
Journal:  Science       Date:  1971-06-11       Impact factor: 47.728

4.  Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity.

Authors:  R G Stoller; K R Hande; S A Jacobs; S A Rosenberg; B A Chabner
Journal:  N Engl J Med       Date:  1977-09-22       Impact factor: 91.245

5.  Treatment of massive intrathecal methotrexate overdose by ventriculolumbar perfusion.

Authors:  R J Spiegel; P R Cooper; R H Blum; J L Speyer; D McBride; J Mangiardi
Journal:  N Engl J Med       Date:  1984-08-09       Impact factor: 91.245

6.  Bleomycin pharmacokinetics in man. I. Intravenous administration.

Authors:  D S Alberts; H S Chen; R Liu; K J Himmelstein; M Mayersohn; D Perrier; J Gross; T Moon; A Broughton; S E Salmon
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

7.  Pharmaco-kinetics of melphalan following oral or intravenous administration in patients with malignant disease.

Authors:  M H Tattersall; M Jarman; E S Newlands; L Holyhead; R A Milstead; A Weinberg
Journal:  Eur J Cancer       Date:  1978-05       Impact factor: 9.162

8.  Metabolic activation of procarbazine.

Authors:  R J Weinkam; D A Shiba
Journal:  Life Sci       Date:  1978-03       Impact factor: 5.037

9.  Oxidative metabolism of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine) by rat liver microsomes.

Authors:  D L Dunn; R A Lubet; R A Prough
Journal:  Cancer Res       Date:  1979-11       Impact factor: 12.701

10.  Sodium thiosulfate inhibits cis-diamminedichloroplatinum (II) activity.

Authors:  J Uozumi; M Ishizawa; Y Iwamoto; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

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  2 in total

1.  Accidental iatrogenic intoxications by cytotoxic drugs: error analysis and practical preventive strategies.

Authors:  B Zernikow; E Michel; G Fleischhack; U Bode
Journal:  Drug Saf       Date:  1999-07       Impact factor: 5.606

Review 2.  Clinical features, pathogenesis and management of drug-induced seizures.

Authors:  G Zaccara; G C Muscas; A Messori
Journal:  Drug Saf       Date:  1990 Mar-Apr       Impact factor: 5.606

  2 in total

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