Literature DB >> 6602716

Dantrolene: evidence for effects on Na permeability properties of the nodal membrane.

J R Schwarz, R P Spielmann.   

Abstract

The effects of dantrolene on myelinated frog nerve fibers were studied in voltage clamp experiments. Dantrolene shifted the potential-dependent parameters describing Na+ permeability towards more negative membrane potentials. The findings are interpreted as a change in the negative surface charge of the membrane.

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Year:  1983        PMID： 6602716     DOI： 10.1007/bf01990310

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  THE ACTION POTENTIAL IN THE MYELINATED NERVE FIBER OF XENOPUS LAEVIS AS COMPUTED ON THE BASIS OF VOLTAGE CLAMP DATA.

Authors:  B FRANKENHAEUSER; A F HUXLEY
Journal:  J Physiol       Date:  1964-06       Impact factor: 5.182

2.  The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-04       Impact factor: 5.182

3.  Dantrolene and A13187 ionophore: specific action on calcium channels revealed by the aequorin method.

Authors:  J E Desmedt; K Hainaut
Journal:  Biochem Pharmacol       Date:  1979-04-01       Impact factor: 5.858

4.  Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant.

Authors:  K O Ellis; J F Carpenter
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

5.  Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium.

Authors:  K O Ellis; S H Bryant
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

6.  Calcium and lanthanum effects at the nodal membrane.

Authors:  W Vogel
Journal:  Pflugers Arch       Date:  1974       Impact factor: 3.657

7.  A new voltage clamp method for Ranvier nodes.

Authors:  W Nonner
Journal:  Pflugers Arch       Date:  1969       Impact factor: 3.657

8.  Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium.

Authors:  W B Van Winkle
Journal:  Science       Date:  1976-09-17       Impact factor: 47.728

Review 9.  Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity.

Authors:  R M Pinder; R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1977-01       Impact factor: 9.546

10.  Inhibition of the intracellular release of calcium by Dantrolene in barnacle giant muscle fibres.

Authors:  J E Desmedt; K Hainaut
Journal:  J Physiol       Date:  1977-02       Impact factor: 5.182
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