Literature DB >> 959824

Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium.

W B Van Winkle.   

Abstract

The muscle relaxant dantrolene sodium acts directly and specifically on skeletal muscle, unlike other pharmacological agents which affect the central nervous system or act at the nueromuscular junction. Dantrolene sodium markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac, muscle sarcoplasmic reticulum. No effect in the total amount of calcium accumulated was found. In situ, the drug may reduce the amount of calcium necessary for muscle contraction.

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Year:  1976        PMID： 959824     DOI： 10.1126/science.959824

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  33 in total

1.  The biphasic force-velocity relationship in frog muscle fibres and its evaluation in terms of cross-bridge function.

Authors:  K A Edman; A Månsson; C Caputo
Journal:  J Physiol       Date:  1997-08-15       Impact factor: 5.182

2.  Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle.

Authors:  S S Palnitkar; J R Mickelson; C F Louis; J Parness
Journal:  Biochem J       Date:  1997-09-15       Impact factor: 3.857

3.  A model for the uptake and release of Ca2+ by sarcoplasmic reticulum.

Authors:  G W Gould; J M McWhirter; J M East; A G Lee
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

4.  Effects of dantrolene on force development in slow- and fast-twitch muscle of euthyroid, hypothyroid, and hyperthyroid rats.

Authors:  M E Everts; C van Hardeveld
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

5.  Characterization of Ca2+ uptake and release by vesicles of skeletal-muscle sarcoplasmic reticulum.

Authors:  J M McWhirter; G W Gould; J M East; A G Lee
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

6.  The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibres.

Authors:  K A Edman
Journal:  J Physiol       Date:  1979-06       Impact factor: 5.182

7.  The action of dantrolene sodium on individual fast and slow motor units of the rat anaesthetized with urethane.

Authors:  G C Leslie; N J Part
Journal:  Br J Pharmacol       Date:  1984-02       Impact factor: 8.739

8.  Relationship between plasma concentration and effect of dantrolene sodium in man.

Authors:  W J Meyler; H W Mols-Thürkow; H Wesseling
Journal:  Eur J Clin Pharmacol       Date:  1979-09       Impact factor: 2.953

Review 9.  Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.

Authors:  A Ward; M O Chaffman; E M Sorkin
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

10.  Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia.

Authors:  José M Eltit; Xudong Ding; Isaac N Pessah; Paul D Allen; José R Lopez
Journal:  FASEB J       Date:  2012-11-16       Impact factor: 5.191
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