Literature DB >> 6595964

Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy.

J R Rodríguez, E L Mariño, M J Otero, J R Commes, J Garcia, J M Rodriguez, F Lozano, A Dominguez-Gil, A G Alonso.   

Abstract

The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle.

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Year:  1984        PMID： 6595964      PMCID： PMC180017          DOI： 10.1128/AAC.26.5.787

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  3 in total

1.  The effect of an antibiotic spray in the prevention of wound infection. A controlled trial.

Authors:  D W Jackson; A V Pollock; D S Tindal
Journal:  Br J Surg       Date:  1971-08       Impact factor: 6.939

2.  Postoperative wound infection: a computer analysis.

Authors:  A E Davidson; C Clark; G Smith
Journal:  Br J Surg       Date:  1971-05       Impact factor: 6.939

3.  High-performance liquid chromatographic method for determination of cefmetazole in human serum.

Authors:  M Sekine; K Sasahara; T Kojima; T Morioka
Journal:  Antimicrob Agents Chemother       Date:  1982-05       Impact factor: 5.191
  3 in total
  5 in total

1.  Pharmacokinetic parameters from data relating to the plasma and biliary excretion kinetics of cefmetazole in rats.

Authors:  M J García-Agundez; C Fernández-Lastra; R Jiménez; J González; E L Mariño
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1992 Jul-Sep       Impact factor: 2.441

2.  Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers.

Authors:  M T Borin; G R Peters; T C Smith
Journal:  Antimicrob Agents Chemother       Date:  1990-10       Impact factor: 5.191

3.  Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults.

Authors:  J Rodriguez-Barbero; E L Mariño; A Dominguez-Gil
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191

4.  Pharmacokinetics of single-dose cefmetazole following intramuscular administration of cefmetazole sodium to healthy male volunteers.

Authors:  H Ko; E Novak; G R Peters; W M Bothwell; J D Hosley; S K Closson; W J Adams
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

5.  Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.

Authors:  H Ko; K S Cathcart; D L Griffith; G R Peters; W J Adams
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191
  5 in total

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