Literature DB >> 659426

Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure.

J A Holden, W N Kelley.   

Abstract

Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) has been purified 23,000-fold from normal human erythrocytes. The purification includes affinity chromatography on a GMP column. The subunit molecular weight of the enzyme obtained from this purification is 24,000. The finding of four protein species after cross-linkage of the highly purified enzyme with dimethylsuberimidate, dimethyladipimidate, and glutaraldehyde suggests that the enzyme may exist in the native state as a tetramer.

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Year:  1978        PMID： 659426

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  17 in total

1.  Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

Authors:  T D Palella; L J Silverman; C T Schroll; F L Homa; M Levine; W N Kelley
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

Review 2.  Are proteins made of modules?

Authors:  T W Traut
Journal:  Mol Cell Biochem       Date:  1986-04       Impact factor: 3.396

3.  Partial purification and characterization of the mRNA for human thymidine kinase and hypoxanthine/guanine phosphoribosyltransferase.

Authors:  P F Lin; M Yamaizumi; P D Murphy; A Egg; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

4.  Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts.

Authors:  B L Davidson; S A Tarlé; T D Palella; W N Kelley
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

5.  Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout.

Authors:  J M Wilson; G E Tarr; W N Kelley
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

6.  Human adenine phosphoribosyltransferase: characterization from subjects with a deficiency of enzyme activity.

Authors:  T E O'Toole; J M Wilson; M H Gault; W N Kelley
Journal:  Biochem Genet       Date:  1983-12       Impact factor: 1.890

7.  Human hypoxanthine-guanine phosphoribosyltransferase. Demonstration of structural variants in lymphoblastoid cells derived from patients with a deficiency of the enzyme.

Authors:  J M Wilson; B W Baugher; P M Mattes; P E Daddona; W N Kelley
Journal:  J Clin Invest       Date:  1982-03       Impact factor: 14.808

8.  Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome.

Authors:  J M Wilson; W N Kelley
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

9.  Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy.

Authors:  S P Craig; J H McKerrow; G R Newport; C C Wang
Journal:  Nucleic Acids Res       Date:  1988-07-25       Impact factor: 16.971

10.  A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man.

Authors:  J M Wilson; J T Stout; T D Palella; B L Davidson; W N Kelley; C T Caskey
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808
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