Albright's syndrome with reactivation of fibrous dysplasia secondary to pituitary adenoma and further complicated by osteogenic sarcoma. Report of a case.

To our knowledge, this is the only reported case of Albright's syndrome with reactivation of the fibrous dysplasia in adulthood, a marked elevation of growth hormone secondary to a pituitary adenoma, and development of osteosarcoma within the reactivated fibrous dysplasia. In addition, this patient also had hyperthyroidism with normal TSH levels, indicating the presence of two separate endocrinopathies. Reactivation of the fibrous dysplasia after years of arrested growth in this patient is good evidence that fibrous dysplasia does not "burn out" after adolescence but that growth ceases only when growth hormone declines to adult levels.