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Literature DB >> 18521394

Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy.

Robert S Lee¹, Deborah Higgs, Omar Haddo, Jean Pringle, Timothy W R Briggs.

Abstract

PURPOSE: Diamond-Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported, with five cases of osteosarcoma described. PATIENT: A sixth case of a 12-year-old girl with DBA who developed an osteosarcoma of the distal femur is presented.
RESULTS: She was treated with methotrexate followed by tumour excision and distal femoral replacement. The patient is currently alive with multiple pulmonary metastases. DISCUSSION: We discuss the association between the administration of growth hormone and future development of malignancy in patients with DBA.

Entities: Chemical Disease Gene Species

Year: 2004 PMID： 18521394 PMCID： PMC2395602 DOI： 10.1080/13577140410001679266

Source DB: PubMed Journal: Sarcoma ISSN： 1357-714X

8 in total

1. Identification of new prognosis factors from the clinical and epidemiologic analysis of a registry of 229 Diamond-Blackfan anemia patients. DBA group of Société d'Hématologie et d'Immunologie Pédiatrique (SHIP), Gesellshaft für Pädiatrische Onkologie und Hämatologie (GPOH), and the European Society for Pediatric Hematology and Immunology (ESPHI).

Authors: T N Willig; C M Niemeyer; T Leblanc; C Tiemann; A Robert; J Budde; A Lambiliotte; E Kohne; G Souillet; S Eber; J L Stephan; R Girot; P Bordigoni; G Cornu; S Blanche; J M Guillard; N Mohandas; G Tchernia
Journal: Pediatr Res Date: 1999-11 Impact factor: 3.756

2. Osteogenic sarcoma associated with Diamond-Blackfan anemia: a report from the Diamond-Blackfan Anemia Registry.

Authors: J M Lipton; N Federman; Y Khabbaze; C L Schwartz; L M Hilliard; J I Clark; A Vlachos
Journal: J Pediatr Hematol Oncol Date: 2001-01 Impact factor: 1.289

3. Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone.

Authors: J Pinski; A V Schally; K Groot; G Halmos; K Szepeshazi; M Zarandi; P Armatis
Journal: J Natl Cancer Inst Date: 1995-12-06 Impact factor: 13.506

4. Effects of recombinant human insulin-like growth factor I and II (IGF-I/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells.

Authors: B A Scheven; N J Hamilton; T M Fakkeldij; S A Duursma
Journal: Growth Regul Date: 1991-12

Review 5. Osteogenic sarcoma in a child with transfusion-dependent Diamond-Blackfan anemia.

Authors: V M Aquino; G R Buchanan
Journal: J Pediatr Hematol Oncol Date: 1996-05 Impact factor: 1.289

6. Albright's syndrome with reactivation of fibrous dysplasia secondary to pituitary adenoma and further complicated by osteogenic sarcoma. Report of a case.

Authors: M B Hall; A G Sclar; D F Gardner
Journal: Oral Surg Oral Med Oral Pathol Date: 1984-06

7. Follow-up height after discontinuation of growth hormone treatment in children with intrauterine growth retardation.

Authors: Feyza Darendeliler; Rüveyde Bundak; Sema Kabataş Eryilmaz; Hülya Günöz; Firdevs Baş; Nurçin Saka
Journal: J Pediatr Endocrinol Metab Date: 2002-06 Impact factor: 1.634

8. Inhibition of proliferation in human MNNG/HOS osteosarcoma and SK-ES-1 Ewing sarcoma cell lines in vitro and in vivo by antagonists of growth hormone-releasing hormone: effects on insulin-like growth factor II.

Authors: Ryszard Braczkowski; Andrew V Schally; Artur Plonowski; Jozsef L Varga; Kate Groot; Magdalena Krupa; Patricia Armatis
Journal: Cancer Date: 2002-10-15 Impact factor: 6.860

8 in total

4 in total

Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy.

2. Osteogenic sarcoma associated with Diamond-Blackfan anemia: a report from the Diamond-Blackfan Anemia Registry.

3. Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone.

4. Effects of recombinant human insulin-like growth factor I and II (IGF-I/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells.

Review 5. Osteogenic sarcoma in a child with transfusion-dependent Diamond-Blackfan anemia.

6. Albright's syndrome with reactivation of fibrous dysplasia secondary to pituitary adenoma and further complicated by osteogenic sarcoma. Report of a case.

7. Follow-up height after discontinuation of growth hormone treatment in children with intrauterine growth retardation.

8. Inhibition of proliferation in human MNNG/HOS osteosarcoma and SK-ES-1 Ewing sarcoma cell lines in vitro and in vivo by antagonists of growth hormone-releasing hormone: effects on insulin-like growth factor II.

Review 1. A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes.

2. At-risk populations for osteosarcoma: the syndromes and beyond.

Review 3. Circulating biomarkers in osteosarcoma: new translational tools for diagnosis and treatment.

Review 4. Genetic Predisposition to Solid Pediatric Cancers.