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Literature DB >> 6587775

Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission.

Abstract

A sample of 35 published pedigrees of Gilles de la Tourette syndrome is studied using complex segregation analysis with pointers. Results indicate the presence of a rare, semidominant, incompletely penetrant allele leading to affection. This result is consistent with that previously reported by Comings et al. on a larger, independent sample.

Entities: Disease

Mesh：

Year: 1984 PMID： 6587775 PMCID： PMC1684450

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

13 in total

1. Gilles de la Tourette syndrome: clinical and genetic studies in a midwestern city.

Authors: E R Wassman; R Eldridge; S Abuzzahab; L Nee
Journal: Neurology Date: 1978-03 Impact factor: 9.910

2. Multiple tic syndrome (Giles de la Tourette's syndrome).

Authors: H Moldofsky; C Tullis; R Lamon
Journal: J Nerv Ment Dis Date: 1974-10 Impact factor: 2.254

3. Analysis of family resemblance. I. Introduction.

Authors: N E Morton
Journal: Am J Hum Genet Date: 1974-05 Impact factor: 11.025

4. Analysis of family resemblance. 3. Complex segregation of quantitative traits.

Authors: N E Morton; C J MacLean
Journal: Am J Hum Genet Date: 1974-07 Impact factor: 11.025

5. Familial pattern of Gilles de la Tourette syndrome.

Authors: K K Kidd; B A Prusoff; D J Cohen
Journal: Arch Gen Psychiatry Date: 1980-12

6. Complex segregation analysis with pointers.

Authors: J M Lalouel; N E Morton
Journal: Hum Hered Date: 1981 Impact factor: 0.444

7. Recurrence risks in complex inheritance with special regard to pyloric stenosis.

Authors: J M Lalouel; N E Morton; C J MacLean; J Jackson
Journal: J Med Genet Date: 1977-12 Impact factor: 6.318

8. Gilles de la Tourette syndrome: clinical and family study of 50 cases.

Authors: L E Nee; E D Caine; R J Polinsky; R Eldridge; M H Ebert
Journal: Ann Neurol Date: 1980-01 Impact factor: 10.422

9. Gilles de la Tourette's syndrome: clinical, genetic, psychologic, and biochemical aspects in 21 selected families.

Authors: R Eldridge; R Sweet; R Lake; M Ziegler; A K Shapiro
Journal: Neurology Date: 1977-02 Impact factor: 9.910

10. Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions.

Authors: L L Heston; A R Mastri; V E Anderson; J White
Journal: Arch Gen Psychiatry Date: 1981-10

15 in total

Review 1. The genetics of Tourette syndrome.

Authors: D L Pauls
Journal: Curr Psychiatry Rep Date: 2001-04 Impact factor: 5.285

2. Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.

Authors: Carol A Mathews; Marco A Grados
Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-11-18 Impact factor: 8.829

3. No evidence for genetic linkage of Gilles de la Tourette syndrome on chromosomes 7 and 18.

Authors: P Heutink; B J van de Wetering; G J Breedveld; J Weber; L A Sandkuyl; E J Devor; A Heiberg; M F Niermeijer; B A Oostra
Journal: J Med Genet Date: 1990-07 Impact factor: 6.318

4. Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance.

Authors: J T Walkup; M C LaBuda; H S Singer; J Brown; M A Riddle; O Hurko
Journal: Am J Hum Genet Date: 1996-09 Impact factor: 11.025

5. Evidence for an X-linked modifier gene affecting the expression of Tourette syndrome and its relevance to the increased frequency of speech, cognitive, and behavioral disorders in males.

Authors: D E Comings; B G Comings
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205