Literature DB >> 6585367

Rapid quantitative determination of seven anthracyclines and their hydroxy metabolites in body fluids.

M J Oosterbaan, R J Dirks, T B Vree, E van der Kleijn.   

Abstract

A reversed-phase high-performance liquid chromatographic method is described for the determination of seven anthracycline analogues and their hydroxy metabolites. The method is suitable for analysis of 30 plasma samples a day. The detection limit is 0.5 ng/ml for all compounds. Examples of the pharmacokinetics of adriamycin and carminomycin in man are shown.

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Year:  1984        PMID: 6585367     DOI: 10.1016/s0378-4347(00)80894-4

Source DB:  PubMed          Journal:  J Chromatogr


  5 in total

Review 1.  Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. II. Assay methods, adriamycin and the other antitumour antibiotics.

Authors:  A G Bosanquet
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

2.  Method for the determination of 4-demethoxydaunorubicin, its quinone and hydroquinone metabolites in human plasma and urine by high-performance liquid chromatography.

Authors:  J Cummings; R Milroy; S W Banham; S B Kaye
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

3.  Sensitive absorption-based wave-mixing detector for anthracycline drugs separated by capillary electrophoresis.

Authors:  Sandrine Berniolles; Hongjing Kan; William G Tong
Journal:  Spectrochim Acta A Mol Biomol Spectrosc       Date:  2010-06-23       Impact factor: 4.098

4.  Erythrocytes as barriers for drug elimination in the isolated rat liver. I. Doxorubicin.

Authors:  H J Lee; W L Chiou
Journal:  Pharm Res       Date:  1989-10       Impact factor: 4.200

Review 5.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25
  5 in total

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