Literature DB >> 6582504

On the mechanism of nucleolar dominance in mouse-human somatic cell hybrids.

T Onishi, C Berglund, R H Reeder.   

Abstract

The mechanism of nucleolar dominance was studied in two lines of mouse-human somatic hybrids. Both lines had preferentially lost human chromosomes but had retained significant amounts of both mouse and human ribosomal genes (genes coding for the 18S, 5.8S, and 28S RNAs of ribosomes). However, the human ribosomal genes were repressed, and only mouse ribosomal genes were expressed. Soluble transcription extracts from the hybrids were able to initiate RNA synthesis accurately on a cloned mouse ribosomal gene but were unable to initiate accurately on a human ribosomal gene. This suggests that nucleolar dominance in these hybrids is due to the loss or inactivation of the gene for a specificity factor required to recognize the human ribosomal gene promoter.

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Year:  1984        PMID： 6582504      PMCID： PMC344702          DOI： 10.1073/pnas.81.2.484

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Expression of human and suppression of mouse nucleolus organizer activity in mouse-human somatic cell hybrids.

Authors:  O J Miller; D A Miller; V G Dev; R Tantravahi; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

2.  Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

Authors:  G K McMaster; G G Carmichael
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

3.  DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

Authors:  J L Manley; A Fire; A Cano; P A Sharp; M L Gefter
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

4.  Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA.

Authors:  P A Weil; D S Luse; J Segall; R G Roeder
Journal:  Cell       Date:  1979-10       Impact factor: 41.582

5.  Reactivation of silent rRNA genes by simian virus 40 in human-mouse hybrid cells.

Authors:  K J Soprano; V G Dev; C M Croce; R Baserga
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

6.  Preferential transcription of Xenopus laevis ribosomal RNA in interspecies hybrids between Xenopus laevis and Xenopus mulleri.

Authors:  T Honjo; R H Reeder
Journal:  J Mol Biol       Date:  1973-10-25       Impact factor: 5.469

7.  Reactivation of ribosomal RNA genes in human-mouse hybrid cells by 12-O-tetradecanoylphorbol 13-acetate.

Authors:  K J Soprano; R Baserga
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

8.  Selective suppression of the transcription of ribosomal genes in mouse-human hybrid cells.

Authors:  R P Perry; D E Kelley; U Schibler; K Huebner; C M Croce
Journal:  J Cell Physiol       Date:  1979-03       Impact factor: 6.384

9.  Spacer regulation of Xenopus ribosomal gene transcription: competition in oocytes.

Authors:  R H Reeder; J G Roan; M Dunaway
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

10.  Suppression of production of mouse 28S ribosomal RNA in mouse-human hybrids segregating mouse chromosomes.

Authors:  C M Croce; A Talavera; C Basilico; O J Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205
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  18 in total

Review 1.  Nucleolar dominance: uniparental gene silencing on a multi-megabase scale in genetic hybrids.

Authors:  C S Pikaard
Journal:  Plant Mol Biol       Date:  2000-06       Impact factor: 4.076

2.  Presence of a limited number of essential nucleotides in the promoter region of mouse ribosomal RNA gene.

Authors:  T Kishimoto; M Nagamine; T Sasaki; N Takakusa; T Miwa; R Kominami; M Muramatsu
Journal:  Nucleic Acids Res       Date:  1985-05-24       Impact factor: 16.971

Review 3.  Transcription of eukaryotic ribosomal RNA gene.

Authors:  S T Jacob
Journal:  Mol Cell Biochem       Date:  1986-04       Impact factor: 3.396

4.  Isolation, fractionation and reconstitution of a nuclear extract capable of transcribing ribosomal DNA.

Authors:  R E Haglund; L I Rothblum
Journal:  Mol Cell Biochem       Date:  1987-01       Impact factor: 3.396

Review 5.  The role of somatic cell genetics in human gene mapping.

Authors:  K H Grzeschik
Journal:  Experientia       Date:  1986-10-15

6.  The absence of a human-specific ribosomal DNA transcription factor leads to nucleolar dominance in mouse greater than human hybrid cells.

Authors:  R Miesfeld; B Sollner-Webb; C Croce; N Arnheim
Journal:  Mol Cell Biol       Date:  1984-07       Impact factor: 4.272

7.  Characterization of a factor that can prevent random transcription of cloned rDNA and its probable relationship to poly(ADP-ribose) polymerase.

Authors:  R N Kurl; S T Jacob
Journal:  Nucleic Acids Res       Date:  1985-01-11       Impact factor: 16.971

8.  Nucleolar dominance and replicative dominance in Drosophila interspecific hybrids.

Authors:  C Goodrich-Young; H M Krider
Journal:  Genetics       Date:  1989-10       Impact factor: 4.562

9.  Cooperative binding of the Xenopus RNA polymerase I transcription factor xUBF to repetitive ribosomal gene enhancers.

Authors:  C D Putnam; C S Pikaard
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

10.  Structural determinant of the species-specific transcription of the mouse rRNA gene promoter.

Authors:  G Safrany; N Tanaka; T Kishimoto; Y Ishikawa; H Kato; R Kominami; M Muramatsu
Journal:  Mol Cell Biol       Date:  1989-01       Impact factor: 4.272
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