Literature DB >> 6582477

Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?

H Koprowski, D Herlyn, M Lubeck, E DeFreitas, H F Sears.   

Abstract

Inoculation of human subjects with mouse monoclonal antibody results in the production of anti-idiotype antibody that reacts with the binding site of the monoclonal antibody. This reaction is hapten-inhibited, suggesting that an internal image of the antigen is produced by the anti-idiotype response. The anti-idiotype antibody isolated from sera of three patients showed significant crossreactivity. Patients who developed the anti-idiotype antibody improved clinically and had long remission from their disease. The possible presence of the internal image of cancer antigen on the human immunoglobulin molecule may change the conditions under which the immune system reacts to the tumor antigen and may open new approaches to the control of tumor growth.

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Year:  1984        PMID： 6582477      PMCID： PMC344642          DOI： 10.1073/pnas.81.1.216

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide.

Authors:  M A Pellegrino; S Ferrone; M P Dierich; R A Reisfeld
Journal:  Clin Immunol Immunopathol       Date:  1975-01

2.  Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody.

Authors:  R A Miller; D G Maloney; R Warnke; R Levy
Journal:  N Engl J Med       Date:  1982-03-04       Impact factor: 91.245

3.  Tumor therapy with monoclonal antibodies.

Authors:  R Levy; R A Miller
Journal:  Fed Proc       Date:  1983-06

4.  Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

Authors:  M Herlyn; Z Steplewski; D Herlyn; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

5.  Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours.

Authors:  H F Sears; B Atkinson; J Mattis; C Ernst; D Herlyn; Z Steplewski; P Häyry; H Koprowski
Journal:  Lancet       Date:  1982-04-03       Impact factor: 79.321

6.  Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma.

Authors:  M Herlyn; H F Sears; Z Steplewski; H Koprowski
Journal:  J Clin Immunol       Date:  1982-04       Impact factor: 8.317

7.  Antigen-specific human T-cell hybridomas with helper activity.

Authors:  E C DeFreitas; S Vella; A Linnenbach; C Zmijewski; H Koprowski; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

8.  IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells.

Authors:  D Herlyn; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

9.  Serotherapy of acute lymphoblastic leukemia with monoclonal antibody.

Authors:  J Ritz; J M Pesando; S E Sallan; L A Clavell; J Notis-McConarty; P Rosenthal; S F Schlossman
Journal:  Blood       Date:  1981-07       Impact factor: 22.113

10.  Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.

Authors:  D L Sacks; K M Esser; A Sher
Journal:  J Exp Med       Date:  1982-04-01       Impact factor: 14.307
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  52 in total

1.  Frequent anti-V-region immune response to mouse B72.3 monoclonal antibody.

Authors:  M B Khazaeli; M N Saleh; T Liu; P M Kaladas; S C Gilman; A F LoBuglio
Journal:  J Clin Immunol       Date:  1992-03       Impact factor: 8.317

Review 2.  Recombinant antibodies for the diagnosis and treatment of cancer.

Authors:  Jürgen Krauss
Journal:  Mol Biotechnol       Date:  2003-09       Impact factor: 2.695

Review 3.  Immunoscintigraphy for cancer detection: "a thousand ills require a thousand cures".

Authors:  S H de Bie; T C Ferreira; E K Pauwels; F J Cleton
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

4.  Monoclonal antibodies: a potentially powerful tool in the diagnosis and treatment of infectious diseases.

Authors:  G Spira; R R Pollock; A Bargellesi; M D Scharff
Journal:  Eur J Clin Microbiol       Date:  1985-06       Impact factor: 3.267

Review 5.  Monoclonal antibodies in cancer therapy.

Authors:  R Gruber; E Holz; G Riethmüller
Journal:  Springer Semin Immunopathol       Date:  1996

Review 6.  Possible role of anti-idiotypic antibodies in the induction of tumor immunity.

Authors:  R C Kennedy; E M Zhou; R E Lanford; T C Chanh; C A Bona
Journal:  J Clin Invest       Date:  1987-11       Impact factor: 14.808

7.  Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I.

Authors:  S Matsushita; M Robert-Guroff; J Trepel; J Cossman; H Mitsuya; S Broder
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

Review 8.  Anti-idiotypic antibodies and the induction of specific tumor immunity.

Authors:  G T Nepom; K E Hellström
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

9.  Human monoclonal anti-idiotypic antibody to the tumour-associated antibody 791T/36.

Authors:  E B Austin; R A Robins; L G Durrant; M R Price; R W Baldwin
Journal:  Immunology       Date:  1989-08       Impact factor: 7.397

10.  Induction of delayed-type hypersensitivity responses by monoclonal anti-idiotypic antibodies to tumor cells expressing carcinoembryonic antigen and tumor-associated glycoprotein-72.

Authors:  K Irvine; J Schlom
Journal:  Cancer Immunol Immunother       Date:  1993-05       Impact factor: 6.968
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