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Literature DB >> 6580903

Stimulatory effect of prostaglandin E2 on 1 alpha,25-dihydroxyvitamin D3 synthesis in rats.

M Yamada, T Matsumoto, N Takahashi, T Suda, E Ogata.

Abstract

The effect of prostaglandin E2 on accumulation in plasma of 1 alpha,25-dihydroxy[3H]vitamin D3 from 25-hydroxy[3H]vitamin D3 was studied in vivo using vitamin D-deficient thyroparathyroidectomized rats. Intra-arterial infusion of 10-50 micrograms of prostaglandin E2/h caused a significant stimulation of 1 alpha,25-dihydroxy[3H]vitamin D3 production. No significant changes in plasma Ca2+ and Pi concentrations or urinary cyclic AMP excretion were observed after prostaglandin E2 infusion. Theophylline did not enhance the effect of a submaximal dose of prostaglandin E2 on 1 alpha,25-dihydroxy[3H]vitamin D3 production. These data indicate that prostaglandin E2 stimulates plasma accumulation of 1 alpha,25-dihydroxy[3H]vitamin D3 independent of the adenylate cyclase/cyclic AMP system, and suggest that prostaglandin E2 has a modulatory role in the regulation of 25-hydroxyvitamin D3 1 alpha-hydroxylase in the kidney.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6580903 PMCID： PMC1152492 DOI： 10.1042/bj2160237

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

29 in total

2. A novel compound heterozygous ROMK mutation presenting as late onset Bartter syndrome associated with nephrocalcinosis and elevated 1,25(OH)(2) vitamin D levels.

Authors: Amita Sharma; Micheal A Linshaw
Journal: Clin Exp Nephrol Date: 2011-03-25 Impact factor: 2.801

2 in total

Stimulatory effect of prostaglandin E2 on 1 alpha,25-dihydroxyvitamin D3 synthesis in rats.

1. Intravenous infusion of prostaglandin E2 raises plasma calcium concentration in the rat.

2. Effect of calcitonin on vitamin D metabolism.

3. A new chromatographic system for vitamin D3 and its metabolites: resoluation of a new vitamin D3 metabolite.

4. Control of 25-hydroxycholecalciferol metabolism by parathyroid glands.

5. Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.

6. Biological activity of 25-hydroxyergocalciferol in rats.

7. Feedback control of vitamin D metabolism by a nuclear action of 1,25-dihydroxycholecalciferol on the kidney.

8. Regulation of 25-hydroxycholecalciferol-1-hydroxylase activity in kidney by parathyroid hormone.

9. The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus.

10. Stimulation of 24,25-dihydroxyvitamin D3 production by 1,25-dihydroxyvitamin D3.

1. Effect of nifedipine on urinary excretion of calcium and calcium-controlling hormones in essential hypercalciuria.

2. A novel compound heterozygous ROMK mutation presenting as late onset Bartter syndrome associated with nephrocalcinosis and elevated 1,25(OH)(2) vitamin D levels.