Literature DB >> 4344734

Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.

H Rasmussen, M Wong, D Bikle, D B Goodman.   

Abstract

Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 x 10(-10) M bovine parathyroid hormone, or by 10(-6) M cyclic AMP. It is inhibited by 10(-9) M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25-dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis.

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Year:  1972        PMID： 4344734      PMCID： PMC292420          DOI： 10.1172/JCI107065

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  12 in total

1.  Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine.

Authors:  M F Holick; H K Schnoes; H F DeLuca; T Suda; R J Cousins
Journal:  Biochemistry       Date:  1971-07-06       Impact factor: 3.162

2.  Unique biosynthesis by kidney of a biological active vitamin D metabolite.

Authors:  D R Fraser; E Kodicek
Journal:  Nature       Date:  1970-11-21       Impact factor: 49.962

3.  Parathyroid function and the renal excretion of 3'5'-adenylic acid.

Authors:  L R Chase; G D Aurbach
Journal:  Proc Natl Acad Sci U S A       Date:  1967-08       Impact factor: 11.205

4.  Further studies on the isolation and charcterization of parathyroid polypeptides.

Authors:  C D Hawker; J D Glass; H Rasmussen
Journal:  Biochemistry       Date:  1966-01       Impact factor: 3.162

5.  A rapidly acting metabolite of vitamin D3.

Authors:  M R Haussler; D W Boyce; E T Littledike; H Rasmussen
Journal:  Proc Natl Acad Sci U S A       Date:  1971-01       Impact factor: 11.205

6.  Study of calcium absorption in man: a kinetic analysis and physiologic model.

Authors:  S J Birge; W A Peck; M Berman; G D Whedon
Journal:  J Clin Invest       Date:  1969-09       Impact factor: 14.808

7.  Parathyroid hormone, 3'5' AMP, Ca++, and renal gluconeogenesis.

Authors:  N Nagata; H Rasmussen
Journal:  Proc Natl Acad Sci U S A       Date:  1970-02       Impact factor: 11.205

8.  "Activation" of vitamin D by the liver.

Authors:  G Ponchon; A L Kennan; H F DeLuca
Journal:  J Clin Invest       Date:  1969-11       Impact factor: 14.808

9.  1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.

Authors:  L G Raisz; C L Trummel; M F Holick; H F DeLuca
Journal:  Science       Date:  1972-02-18       Impact factor: 47.728

10.  Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol.

Authors:  I T Boyle; R W Gray; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1971-09       Impact factor: 11.205
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  52 in total

Review 1.  Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes.

Authors:  Bruce W Hollis; Carol L Wagner
Journal:  J Clin Endocrinol Metab       Date:  2013-10-08       Impact factor: 5.958

Review 2.  Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.

Authors:  Carol L Wagner; Bruce W Hollis; Kalliopi Kotsa; Hana Fakhoury; Spyridon N Karras
Journal:  Rev Endocr Metab Disord       Date:  2017-09       Impact factor: 6.514

Review 3.  Vitamin D and its analogs in chronic renal failure.

Authors:  E Slatopolsky; A J Brown
Journal:  Osteoporos Int       Date:  1997       Impact factor: 4.507

4.  Parathyroidectomy reduces 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in the hypocalcemic vitamin D-deficient chick.

Authors:  B E Booth; H C Tsai; R C Morris
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808

5.  The treatment of hypoparathyroidism with 1alpha-hydroxycholecalciferol.

Authors:  D P Brenton; C E Dent; J M Gertner
Journal:  Calcif Tissue Res       Date:  1977-05

Review 6.  Vitamin D-endocrine system.

Authors:  N H Bell
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

7.  Thyrocalcitonin and the jejunal absorption of calcium, water, and electrolytes in normal subjects.

Authors:  T K Gray; F A Bieberdorf; J S Fordtran
Journal:  J Clin Invest       Date:  1973-12       Impact factor: 14.808

8.  Calcitonin stimulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in hypophosphatemic mice. Evidence that the regulation of calcitriol production is not universally abnormal in X-linked hypophosphatemia.

Authors:  T Nesbitt; B Lobaugh; M K Drezner
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

9.  Inhibition by 1,25 dihydroxycholecalciferol of hormonal secretion of rat parathyroid gland in organ culture.

Authors:  W Y Au
Journal:  Calcif Tissue Int       Date:  1984-07       Impact factor: 4.333

10.  Inhibition of parathyroid hormone secretion by 25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol in the dog.

Authors:  J M Canterbury; S Lerman; A J Claflin; H Henry; A Norman; E Reiss
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808
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