Literature DB >> 6575236

Kasugamycin resistant mutants of Bacillus stearothermophilus lacking the enzyme for the methylation of two adjacent adenosines in 16S ribosomal RNA.

C P Van Buul, J B Damm, P H Van Knippenberg.   

Abstract

Several mutants of B. stearothermophilus have been isolated that are resistant to the antibiotic kasugamycin. One of these is shown to lack dimethylation of two adjacent adenosines in the 16S ribosomal RNA. All mutants that were analyzed biochemically lack the enzyme that is able to methylate this site. Ribosomal sensitivity and resistance to kasugamycin in B. stearothermophilus is therefore, like in E. coli, closely connected with dimethylation of the adenosines.

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Year:  1983        PMID： 6575236     DOI： 10.1007/BF00325912

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  13 in total

1.  Minimal post-transcriptional modification of yeast mitochondrial ribosomal RNA.

Authors:  J Klootwijk; I Klein; L A Grivell
Journal:  J Mol Biol       Date:  1975-09-25       Impact factor: 5.469

2.  Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. III. Purification and properties of the methylating enzyme and methylase-30 S interactions.

Authors:  B Poldermans; L Roza; P H Van Knippenberg
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

3.  Mechanism of kasugamycin resistance in Escherichia coli.

Authors:  T L Helser; J E Davies; J E Dahlberg
Journal:  Nat New Biol       Date:  1972-01-05

4.  Change in methylation of 16S ribosomal RNA associated with mutation to kasugamycin resistance in Escherichia coli.

Authors:  T L Helser; J E Davies; J E Dahlberg
Journal:  Nat New Biol       Date:  1971-09-01

5.  The 3'-terminus of 16 S ribosomal RNA of Escherichia coli. Isolation and purification of the terminal 49-nucleotide fragment at a milligram scale.

Authors:  R A Baan; R van Charldorp; E van Leerdam; P H van Knippenberg; L Bosch; J F de Rooij; J H van Boom
Journal:  FEBS Lett       Date:  1976-12-01       Impact factor: 4.124

6.  Sequence, modified nucleotides and secondary structure at the 3'-end of small ribosomal subunit RNA.

Authors:  R Van Charldorp; P H Van Knippenberg
Journal:  Nucleic Acids Res       Date:  1982-02-25       Impact factor: 16.971

7.  Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16S ribosomal RNA of Escherichia coli. IV. The effect of the methylgroups on ribosomal subunit interaction.

Authors:  B Poldermans; H Bakker; P H Van Knippenberg
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971

8.  Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. II. The effect of the absence of the methyl groups on initiation of protein biosynthesis.

Authors:  B Poldermans; C P Van Buul; P H Van Knippenberg
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

9.  Sequence and secondary structure of the colicin fragment of Bacillus stearothermophilus 16S ribosomal RNA.

Authors:  R Van Charldorp; A M Van Kimmenade; P H Van Knippenberg
Journal:  Nucleic Acids Res       Date:  1981-10-10       Impact factor: 16.971

10.  Adenosine dimethylation of 16S ribosomal RNA: effect of the methylgroups on local conformational stability as deduced from electrophoretic mobility of RNA fragments in denaturing polyacrylamide gels.

Authors:  R Van Charldorp; H A Heus; P H Van Knippenberg
Journal:  Nucleic Acids Res       Date:  1981-01-24       Impact factor: 16.971
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  21 in total

1.  Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution.

Authors:  Heather C O'Farrell; Nagesh Pulicherla; Pooja M Desai; Jason P Rife
Journal:  RNA       Date:  2006-03-15       Impact factor: 4.942

2.  N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops.

Authors:  J P Rife; C S Cheng; P B Moore; S A Strobel
Journal:  Nucleic Acids Res       Date:  1998-08-15       Impact factor: 16.971

3.  Increased kasugamycin sensitivity in Escherichia coli caused by the presence of an inducible erythromycin resistance (erm) gene of Streptococcus pyogenes.

Authors:  A N Suvorov; B van Gemen; P H van Knippenberg
Journal:  Mol Gen Genet       Date:  1988-12

4.  High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).

Authors:  Krzysztof Brzezinski; Zbigniew Dauter; Mariusz Jaskolski
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2012-02-07

5.  An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis?

Authors:  Anna Chao Kaberdina; Witold Szaflarski; Knud H Nierhaus; Isabella Moll
Journal:  Mol Cell       Date:  2009-01-30       Impact factor: 17.970

6.  Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine.

Authors:  Hasan Demirci; Riccardo Belardinelli; Emilia Seri; Steven T Gregory; Claudio Gualerzi; Albert E Dahlberg; Gerwald Jogl
Journal:  J Mol Biol       Date:  2009-03-12       Impact factor: 5.469

7.  Structural basis for binding of RNA and cofactor by a KsgA methyltransferase.

Authors:  Chao Tu; Joseph E Tropea; Brian P Austin; Donald L Court; David S Waugh; Xinhua Ji
Journal:  Structure       Date:  2009-03-11       Impact factor: 5.006

8.  Heterologous Escherichia coli expression, purification and characterization of the GrmA aminoglycoside-resistance methyltransferase.

Authors:  Ivana Moric; Sanja Bajkic; Miloje Savic; Tatjana Ilic Tomic; Graeme L Conn; Branka Vasiljevic
Journal:  Protein J       Date:  2009-10       Impact factor: 2.371

9.  ksgA mutations confer resistance to kasugamycin in Neisseria gonorrhoeae.

Authors:  Paul M Duffin; H Steven Seifert
Journal:  Int J Antimicrob Agents       Date:  2008-12-18       Impact factor: 5.283

10.  The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA.

Authors:  Seok-Ming Toh; Liqun Xiong; Taeok Bae; Alexander S Mankin
Journal:  RNA       Date:  2007-11-19       Impact factor: 4.942
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