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Literature DB >> 6573128

Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system.

N E Morton, A Green, T Dunsworth, A Svejgaard, J Barbosa, S S Rich, L Iselius, P Platz, L P Ryder.

Abstract

HLA phenotypes of cases with insulin-dependent diabetes mellitus (IDDM) and identity by descent of HLA haplotypes in affected sib-pairs support an intermediate model in which morbid risk is increased by one HLA-linked IDDM determinant, and greatly increased by two determinants, which may be qualitatively different in DR3 and DR4 haplotypes. Linkage analysis allowing for gametic disequilibrium reveals no recombination in pedigrees with a DR3/DR4 propositus, but spurious recombination in the remaining pedigrees. This evidence favors interaction of unlinked IDDM determinants to produce affection in a small proportion of heterozygotes for an HLA-linked determinant. Partition of data by HLA type of the propositus (ideally by DR and the complement types jointly) is a powerful method to resolve etiological heterogeneity for HLA-associated diseases.

Entities: Disease Gene

Mesh：

Substances：

Year: 1983 PMID： 6573128 PMCID： PMC1685540

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

15 in total

10. Detection of genetic heterogeneity between families of insulin-dependent diabetes mellitus patients using linkage analysis.

Authors: E L Harris; D K Wagener; J S Dorman; A L Drash
Journal: Am J Hum Genet Date: 1985-01 Impact factor: 11.025

Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system.

1. Sequential tests for the detection of linkage.

2. Analysis of family resemblance. 3. Complex segregation of quantitative traits.

3. HLA and disease: predictions for HLA haplotype sharing in families.

4. Complex segregation analysis with pointers.

5. Resolution of linkage for irregular phenotype systems.

6. A two locus model for juvenile diabetes.

7. Close genetic linkage between diabetes mellitus and kidd blood group.

8. Juvenile insulin-dependent diabetes: a possible susceptibility gene in interaction with HLA.

9. A three-allele model for heterogeneity of juvenile onset insulin-dependent diabetes.

10. Gene dosage and suceptibility to insulin-dependent diabetes.

1. HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes.

2. Insulin-dependent diabetes mellitus: a model for the study of multifactorial disorders.

3. Linkage analysis of "necessary" disease loci versus "susceptibility" loci.

4. Type 1 (insulin-dependent) diabetes and genetic heterogeneity.

5. Segregation analysis incorporating linkage markers. I. Single-locus models with an application to type I diabetes.

6. Statistical properties of maximum likelihood estimators for genetic parameters of HLA-linked diseases.

7. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.

8. Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy.

9. Unusual clustering of diseases in a Canadian Old Colony (Chortitza) Mennonite kindred and community.

10. Detection of genetic heterogeneity between families of insulin-dependent diabetes mellitus patients using linkage analysis.