Literature DB >> 6568976

The molecular basis of cataract formation.

G B Benedek.   

Abstract

The theoretical and experimental basis for the transparency and opacification of the lens is reviewed. The microscopic mechanisms so far established which produce cataract are discussed. The use of quasielastic light scattering spectroscopy to measure in vivo the diffusivity of proteins and to sensitively detect the earliest stages of cataract formation is described.

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Year:  1984        PMID： 6568976     DOI： 10.1002/9780470720875.ch14

Source DB:  PubMed          Journal:  Ciba Found Symp        ISSN： 0300-5208


  6 in total

1.  Determination of dideoxyosone precursors of AGEs in human lens proteins.

Authors:  Mikhail Linetsky; S R Kaid Johar; Jasmin Meltretter; Smitha Padmanabha; Trilok Parmar; Abhay R Vasavada; Monika Pischetsrieder; Ram H Nagaraj
Journal:  Arch Biochem Biophys       Date:  2011-07-28       Impact factor: 4.013

2.  Protein size resolution in human eye lenses by dynamic light scattering after in vivo measurements.

Authors:  K Dierks; M Dieckmann; D Niederstrasser; R Schwartz; A Wegener
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1998-01       Impact factor: 3.117

3.  Suppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.

Authors:  J Pande; C Berland; M Broide; O Ogun; J Melhuish; G Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

4.  Phase separation in aqueous solutions of lens gamma-crystallins: special role of gamma s.

Authors:  C Liu; N Asherie; A Lomakin; J Pande; O Ogun; G B Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

5.  Phase separation in lens cytoplasm is genetically linked to cataract formation in the Philly mouse.

Authors:  J I Clark; D Carper
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

6.  Oxidation of gamma II-crystallin solutions yields dimers with a high phase separation temperature.

Authors:  J Pande; A Lomakin; B Fine; O Ogun; I Sokolinski; G Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-14       Impact factor: 11.205
  6 in total

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