Literature DB >> 6561069

Enhanced K-cell activity in the peripheral blood of patients with malignant disease.

T Bakács, P Czanik, I Kimber, G Ringwald, M Moore, E Abrahám.   

Abstract

We have analysed the influence of human malignant, inflammatory and infectious disease on the capacity of peripheral lymphocytes to mediate antibody-dependent haemolysis. The application of an enzyme-like kinetic model for measurement of maximal cytotoxic function has permitted reproducible and sensitive determinations of the K-cell function. The results show that malignant disease is associated with enhancement of ADCC capacity.

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Year:  1984        PMID： 6561069     DOI： 10.1007/bf00205424

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  22 in total

1.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

2.  Specific killing of tumor cells in vitro in the presence of normal lymphoid cells and sera from hosts immune to the tumor antigens.

Authors:  S Pollack; G Heppner; R J Brawn; K Nelson
Journal:  Int J Cancer       Date:  1972-03-15       Impact factor: 7.396

3.  Lymphocyte mediated natural cytotoxicity in neoplasia.

Authors:  M Menon; S S Stefani
Journal:  Oncology       Date:  1978       Impact factor: 2.935

4.  Lysis of alloantibody-sensitized human erythrocytes by peripheral blood mononuclear cells: heterogeneity of effector populations.

Authors:  I Kimber; M Moore
Journal:  J Clin Lab Immunol       Date:  1981-01

5.  Is antibody-dependent cellular cytotoxicity an important mechanism of resistance to tumors in vivo?

Authors:  G Cavallo; M Giovarelli; G Forni; S Landolfo
Journal:  Immunochemistry       Date:  1978-11

6.  In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

Authors:  S Habu; H Fukui; K Shimamura; M Kasai; Y Nagai; K Okumura; N Tamaoki
Journal:  J Immunol       Date:  1981-07       Impact factor: 5.422

7.  Decline of natural nonselective cell-mediated cytotoxicity in patients with tumor progression.

Authors:  M Takasugi; A Ramseyer; J Takasugi
Journal:  Cancer Res       Date:  1977-02       Impact factor: 12.701

8.  Cytotoxic activity of human lymphocytes: quanitative analysis of T cell and K cell cytotoxicity, revealing enzyme-like kinetics.

Authors:  W P Zeijlemaker; R H van Oers; R E de Goede; P T Schellekens
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

9.  Antibody-dependent cellular cytotoxicity-mediated serotherapy against murine neuroblastoma. I. In vitro and in vivo treatment using normal, gamma-irradiated and immune-stimulated rat effector cells.

Authors:  J E Byfield; R Zerubavel; E W Fonkalsrud
Journal:  Cancer Immunol Immunother       Date:  1982       Impact factor: 6.968

10.  In vitro NK-activity and in vivo resistance to leukemia: studies of beige, beige//nude and wild-type hosts on C57BL background.

Authors:  K Kärre; G O Klein; R Kiessling; G Klein; J C Roder
Journal:  Int J Cancer       Date:  1980-12-15       Impact factor: 7.396
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  1 in total

Review 1.  Immune surveillance and natural resistance: an evaluation.

Authors:  W Den Otter
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968
  1 in total

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