Literature DB >> 656054

The precise and entire antigenic structure of native lysozyme.

M Z Atassi, C L Lee.   

Abstract

The exact boundary, residue, conformational and directional definitions of the three antigenic sites of native hen's egg-white lysozyme are described. The results clearly reveal that the three antigenic sites account quantitatively for the total antigenic reactivity of the protein. Thus the entire antigenic structure of lysozyme has now been precisely determined and is briefly discussed here, together with the power of the surface-stimulation synthetic concept.

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Year:  1978        PMID： 656054      PMCID： PMC1183972          DOI： 10.1042/bj1710429

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Can an antibody-combining site be mimicked synthetically? The possible surface simulation synthesis of two antibody-combining sites complementary to two antigenic sites of lysozyme.

Authors:  M Z Atassi; W Zablocki
Journal:  J Biol Chem       Date:  1977-12-25       Impact factor: 5.157

2.  Enzymic and immunochemical properties of lysozyme. XIII. Accurate delineation of the reactive site around the disulfide 6-127 by immunochemical study of beta-propiolactone lysozyme derivative and of synthetic disulfide peptides.

Authors:  M Z Atassi; J Koketsu; A F Habeeb
Journal:  Biochim Biophys Acta       Date:  1976-02-20

3.  On the conformation of the hen egg-white lysozyme molecule.

Authors:  C C Blake; G A Mair; A C North; D C Phillips; V R Sarma
Journal:  Proc R Soc Lond B Biol Sci       Date:  1967-04-18

4.  Enzymic and immunochemical properties of lysozyme. VII. Location of all the antigenic reactive regions. A new approach to study immunochemistry of tight proteins.

Authors:  M Z Atassi; A F Habeeb; K Ando
Journal:  Biochim Biophys Acta       Date:  1973-03-23

5.  Structure at 4.5 A resolution of a phosphorylcholine-binding fab.

Authors:  E A Padlan; D M Segal; T F Spande; D R Davies; S Rudikoff; M Potter
Journal:  Nat New Biol       Date:  1973-10-10

6.  Enzymic and immunochemical properties of lysozyme. XVI. A novel synthetic approach to an antigenic reactive site by direct linkage of the relevant conformationally adjacent residues constituting the site.

Authors:  M Z Atassi; C L Lee; R C Pai
Journal:  Biochim Biophys Acta       Date:  1976-04-14

7.  Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.

Authors:  M Z Atassi; C L Lee
Journal:  Biochem J       Date:  1978-05-01       Impact factor: 3.857

8.  Delineation of the third antigenic site of lysozyme by application of a novel 'surface-simulation' synthetic approach directly linking the conformationally adjacent residues forming the site.

Authors:  C L Lee; M Z Atassi
Journal:  Biochem J       Date:  1976-10-01       Impact factor: 3.857

9.  Enzymic and immunochemical properties of lysozyme. XI. Conformation and immunochemistry of the two-disulfide peptide and the tryptophan and lysine residues in its antigenic reactivity.

Authors:  C L Lee; M Z Atassi
Journal:  Biochim Biophys Acta       Date:  1975-10-20

10.  Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis.

Authors:  C L Lee; M Z Atassi
Journal:  Biochem J       Date:  1977-12-01       Impact factor: 3.857
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  19 in total

1.  Characterization of antibodies to chicken riboflavin carrier protein. Immunoneutralizing ability of antibodies to a sequence-specific region of the protein.

Authors:  U Natraj; S George; M S Kadam
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857

2.  Distance calculation of residues neighbouring to lysozyme antigenic sites. Site-neighbouring residues whose evolutionary substitution can modify the characteristics and binding energy of the sites.

Authors:  M Z Atassi; A L Kazim
Journal:  Biochem J       Date:  1980-04-01       Impact factor: 3.857

Review 3.  Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.

Authors:  M Z Atassi
Journal:  Mol Cell Biochem       Date:  1980-08-29       Impact factor: 3.396

4.  Prediction of protein antigenic determinants from amino acid sequences.

Authors:  T P Hopp; K R Woods
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

5.  The sequence-immunology correlation revisited: data for cetacean myoglobins and mammalian lysozymes.

Authors:  E M Prager
Journal:  J Mol Evol       Date:  1993-10       Impact factor: 2.395

6.  Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene.

Authors:  U Rüther; M Koenen; A E Sippel; B Müller-Hill
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

7.  Antibodies against a synthetic peptide of the poliovirus replicase protein: reaction with native, virus-encoded proteins and inhibition of virus-specific polymerase activities in vitro.

Authors:  M H Baron; D Baltimore
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

8.  Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.

Authors:  M Z Atassi; S Sakata
Journal:  Biochem J       Date:  1982-03-01       Impact factor: 3.857

9.  Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.

Authors:  M Z Atassi; C L Lee
Journal:  Biochem J       Date:  1978-05-01       Impact factor: 3.857

10.  Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme.

Authors:  M Z Atassi; T Manshouri
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205
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