Literature DB >> 6548169

Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites.

S C Roerig, S M O'Brien, J M Fujimoto, G L Wilcox.   

Abstract

Mice injected with morphine at both a supraspinal (intracerebroventricular) and a spinal (intrathecal) site showed a multiplicative interaction between sites for the tail-flick analgesic response. In morphine pellet-implanted mice, the decrease in this interaction was the source of tolerance developed to subcutaneous morphine whereas the separate sites showed no tolerance. During morphine withdrawal (after removal of the morphine pellet) synergism between sites returned but the separate sites showed development of tolerance.

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Year:  1984        PMID： 6548169     DOI： 10.1016/0006-8993(84)91078-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.

Authors:  T W Vanderah; N M Suenaga; M H Ossipov; T P Malan; J Lai; F Porreca
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

2.  When it comes to opiates, just say NO.

Authors:  Gavril W Pasternak
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808

3.  Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain.

Authors:  Benjamin Storek; Matthias Reinhardt; Cheng Wang; William G M Janssen; Nina M Harder; Michaela S Banck; John H Morrison; Andreas S Beutler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-22       Impact factor: 11.205

Review 4.  Mu opioids and their receptors: evolution of a concept.

Authors:  Gavril W Pasternak; Ying-Xian Pan
Journal:  Pharmacol Rev       Date:  2013-09-27       Impact factor: 25.468

5.  The effect of acute morphine on delay discounting in dependent and non-dependent rats.

Authors:  Colin Harvey-Lewis; Keith B J Franklin
Journal:  Psychopharmacology (Berl)       Date:  2014-09-05       Impact factor: 4.530

6.  Neostigmine interactions with non steroidal anti-inflammatory drugs.

Authors:  Hugo F Miranda; Fernando Sierralta; Gianni Pinardi
Journal:  Br J Pharmacol       Date:  2002-04       Impact factor: 8.739

7.  Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance.

Authors:  Jennifer Y Xie; David S Herman; Carl-Olav Stiller; Luis R Gardell; Michael H Ossipov; Josephine Lai; Frank Porreca; Todd W Vanderah
Journal:  J Neurosci       Date:  2005-01-12       Impact factor: 6.167

8.  Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance.

Authors:  L J Sim-Selley; K L Scoggins; M P Cassidy; L A Smith; W L Dewey; F L Smith; D E Selley
Journal:  Br J Pharmacol       Date:  2007-06-18       Impact factor: 8.739

9.  Combination Drug Therapy for Pain following Chronic Spinal Cord Injury.

Authors:  Aldric Hama; Jacqueline Sagen
Journal:  Pain Res Treat       Date:  2012-03-18
  9 in total

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