Literature DB >> 6547913

Inhibition of free radical-induced DNA damage by uric acid.

A M Cohen, R E Aberdroth, P Hochstein.   

Abstract

Single-strand DNA breaks were produced in isolated rat liver nuclei incubated with 3 separate oxygen free radical generating systems: xanthine oxidase-acetaldehyde plus Fe(II); hematin-R(H)OOH; Fe(II)-H2O2. Uric acid inhibited the induction of damage in the first two systems only. At concentrations below those found in human plasma, it was particularly effective against strand breaks produced by hematin-cumene hydroperoxide. These results offer additional evidence that uric acid may function as a cellular protective agent against superoxide and hydroperoxyl free radical-induced cytotoxicity toxicity.

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Year:  1984        PMID： 6547913     DOI： 10.1016/0014-5793(84)81094-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?

Authors:  M Grootveld; B Halliwell
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

2.  Analysis of S-nitroso-N-acetylpenicillamine effects on dopamine release in the striatum of freely moving rats: role of endogenous ascorbic acid and oxidative stress.

Authors:  P A Serra; G Esposito; M R Delogu; R Migheli; G Rocchitta; E Miele; M S Desole; M Miele
Journal:  Br J Pharmacol       Date:  2001-02       Impact factor: 8.739

3.  Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease.

Authors:  P A Serra; G Esposito; P Enrico; M A Mura; R Migheli; M R Delogu; M Miele; M S Desole; G Grella; E Miele
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

Review 4.  Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.

Authors:  Sara Cipriani; Xiqun Chen; Michael A Schwarzschild
Journal:  Biomark Med       Date:  2010-10       Impact factor: 2.851

5.  Analysis of 3-morpholinosydnonimine and sodium nitroprusside effects on dopamine release in the striatum of freely moving rats: role of nitric oxide, iron and ascorbic acid.

Authors:  P A Serra; G Esposito; M R Delogu; R Migheli; G Rocchitta; G Grella; E Miele; M Miele; M S Desole
Journal:  Br J Pharmacol       Date:  2000-10       Impact factor: 8.739

Review 6.  Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated Review.

Authors:  Priyajit Banerjee; Ishita Saha; Diptendu Sarkar; Arpan Kumar Maiti
Journal:  Neurotox Res       Date:  2022-04-07       Impact factor: 3.911

Review 7.  Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.

Authors:  Huajun Jin; Arthi Kanthasamy; Anamitra Ghosh; Vellareddy Anantharam; Balaraman Kalyanaraman; Anumantha G Kanthasamy
Journal:  Biochim Biophys Acta       Date:  2013-09-20

Review 8.  Comorbidities in patients with crystal diseases and hyperuricemia.

Authors:  Sebastian E Sattui; Jasvinder A Singh; Angelo L Gaffo
Journal:  Rheum Dis Clin North Am       Date:  2014-02-19       Impact factor: 2.670

9.  Metabolomic study of collagen-induced arthritis in rats and the interventional effects of huang-lian-jie-du-tang, a traditional chinese medicine.

Authors:  Rongcai Yue; Ling Zhao; Yaohua Hu; Peng Jiang; Shuping Wang; Li Xiang; Wencong Liu; Lei Shan; Weidong Zhang; Runhui Liu
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-06       Impact factor: 2.629

Review 10.  Oxidation of DNA bases by tumor promoter-activated processes.

Authors:  K Frenkel
Journal:  Environ Health Perspect       Date:  1989-05       Impact factor: 9.031
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