Literature DB >> 6546794

Sequence of human adenosine deaminase cDNA including the coding region and a small intron.

D A Wiginton, G S Adrian, J J Hutton.   

Abstract

The nucleotide sequence for an unusual, cloned human adenosine deaminase cDNA has been determined. Contained within a sequence of 1535 nucleotides is a coding sequence of 1089 nucleotides that encodes a protein of 40,762 daltons. The coding sequence is interrupted by a non-coding region containing 76 nucleotides. Both the 3' and 5' ends of this region have consensus sequences generally associated with splice sites. The 3' untranslated sequence contained 308 nucleotides, including a polyadenylation signal sequence 20 nucleotides from the end. The cloned cDNA appears to correspond to a nuclear mRNA precursor which contains a small intron.

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Year:  1984        PMID： 6546794      PMCID： PMC318674          DOI： 10.1093/nar/12.5.2439

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  23 in total

1.  Human adenosine deaminase. Purification and subunit structure.

Authors:  P E Daddona; W N Kelley
Journal:  J Biol Chem       Date:  1977-01-10       Impact factor: 5.157

2.  A simple method to recover intact high molecular weight RNA and DNA after electrophoretic separation in low gelling temperature agarose gels.

Authors:  L Wieslander
Journal:  Anal Biochem       Date:  1979-10-01       Impact factor: 3.365

3.  Sequence at the 3' end of globin mRNA shows homology with immunoglobulin light chain mRNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1974-11-29       Impact factor: 49.962

4.  Assignment of a gene for adenosine deaminase to human chromosome 20.

Authors:  J A Tischfield; R P Creagan; E A Nichols; F H Ruddle
Journal:  Hum Hered       Date:  1974       Impact factor: 0.444

5.  Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.

Authors:  E R Giblett; J E Anderson; F Cohen; B Pollara; H J Meuwissen
Journal:  Lancet       Date:  1972-11-18       Impact factor: 79.321

Review 6.  Adenosine deaminase deficiency and severe combined immunodeficiency disease.

Authors:  L F Thompson; J E Seegmiller
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1980

7.  Speculations on RNA splicing.

Authors:  P A Sharp
Journal:  Cell       Date:  1981-03       Impact factor: 41.582

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Human adenosine deaminase and its binding protein in normal and adenosine deaminase-deficient fibroblast cell strains.

Authors:  P E Daddona; M A Frohman; W N Kelley
Journal:  J Biol Chem       Date:  1980-06-25       Impact factor: 5.157

10.  Erythrocyte adenosine deaminase deficiency without immunodeficiency. Evidence for an unstable mutant enzyme.

Authors:  R Hirschhorn; V Roegner; T Jenkins; C Seaman; S Piomelli; W Borkowsky
Journal:  J Clin Invest       Date:  1979-10       Impact factor: 14.808
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  18 in total

1.  Identification and characterization of nine RFLPs at the adenosine deaminase (ADA) locus.

Authors:  S Tzall; A Ellenbogen; F Eng; R Hirschhorn
Journal:  Am J Hum Genet       Date:  1989-06       Impact factor: 11.025

Review 2.  The map of chromosome 20.

Authors:  N E Simpson
Journal:  J Med Genet       Date:  1988-12       Impact factor: 6.318

3.  Cell type-specific transcriptional regulation of the human adenosine deaminase gene.

Authors:  D L Lattier; J C States; J J Hutton; D A Wiginton
Journal:  Nucleic Acids Res       Date:  1989-02-11       Impact factor: 16.971

4.  Homozygosity for a newly identified missense mutation in a patient with very severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID).

Authors:  R Hirschhorn; V Chakravarti; J Puck; S D Douglas
Journal:  Am J Hum Genet       Date:  1991-10       Impact factor: 11.025

5.  Structure of adenosine deaminase mRNAs from normal and adenosine deaminase-deficient human cell lines.

Authors:  G S Adrian; D A Wiginton; J J Hutton
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

6.  Correct splicing despite mutation of the invariant first nucleotide of a 5' splice site: a possible basis for disparate clinical phenotypes in siblings with adenosine deaminase deficiency.

Authors:  F X Arredondo-Vega; I Santisteban; S Kelly; C M Schlossman; D T Umetsu; M S Hershfield
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

7.  Mutations in the human adenosine deaminase gene that affect protein structure and RNA splicing.

Authors:  A L Akeson; D A Wiginton; J C States; C M Perme; M R Dusing; J J Hutton
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype.

Authors:  I Santisteban; F X Arredondo-Vega; S Kelly; A Mary; A Fischer; D S Hummell; A Lawton; R U Sorensen; E R Stiehm; L Uribe
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

9.  Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution.

Authors:  S H Orkin; S C Goff; W N Kelley; P E Daddona
Journal:  Mol Cell Biol       Date:  1985-04       Impact factor: 4.272

10.  Characterization of normal and mutant adenosine deaminase messenger RNAs by translation and hybridization to a cDNA probe.

Authors:  G S Adrian; D A Wiginton; J J Hutton
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132
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