Literature DB >> 6543695

Effects of DTIC, DM-COOK and ICRF-159 on the number of circulating Lewis lung carcinoma cells detected by flow cytometry.

T Giraldi, G Sava, R Cherubino, G Bottiroli, G Mazzini.   

Abstract

Circulating tumor cells can be detected by means of flow cytometry in the blood of mice bearing i.m. Lewis lung carcinoma. This technique can be applied in the case of aneuploid tumors and does not require either concentration of nucleated cells or other processing of the blood samples. It offers the advantages of simplicity and speed and allows quantitative measurement of the number of circulating tumor cells. It can be applied to the study of the effects of drug treatment on the number of circulating tumor cells, for those drugs which do not cause alterations in the nuclear DNA content of normal diploid blood cells. The number of circulating tumor cells determined by flow cytometry is markedly reduced by treatment with ICRF-159, by dimethyltriazene DM-COOK, and also by its clinically used analog, DTIC.

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Year:  1984        PMID： 6543695     DOI： 10.1007/bf00052415

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  25 in total

1.  Urinary cytology automation. Preliminary studies with acridine orange stain and flow-through cytofluorometry.

Authors:  M R Melamed; F Traganos; T Sharpless; Z Darzynkiewicz
Journal:  Invest Urol       Date:  1976-03

2.  Flow microfluorometric system for screening gynecologic cytology specimens using propidium iodide-fluorescein isothiocyanate.

Authors:  B J Fowlkes; C J Herman; M Cassidy
Journal:  J Histochem Cytochem       Date:  1976-01       Impact factor: 2.479

3.  A simplified method of evaluating dose-effect experiments.

Authors:  J T LITCHFIELD; F WILCOXON
Journal:  J Pharmacol Exp Ther       Date:  1949-06       Impact factor: 4.030

4.  Early detection of micrometastases via flow microfluorimetry.

Authors:  M Grattarola; S Zietz; S Lessin; C Desaive; C Nicolini
Journal:  Cancer Biochem Biophys       Date:  1979

5.  Antimetastatic action and hematological toxicity of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt and 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide used as prophylactic adjuvants to surgical tumor removal in mice bearing B16 melanoma.

Authors:  G Sava; T Giraldi; L Lassiani; C Nisi
Journal:  Cancer Res       Date:  1984-01       Impact factor: 12.701

6.  Sequential vincristine, arabinosylcytosine and adriamycin in acute leukemia: cytologic and cytokinetic studies.

Authors:  A Riccardi; G Mazzini; C Montecucco; R Cresci; E Traversi; C Berzuini; E Ascari
Journal:  Cytometry       Date:  1982-09

7.  Biophysical identification and sorting of high metastatic variants from B16 melanoma tumor.

Authors:  S R Lessin; S R Abraham; C Nicolini
Journal:  Cytometry       Date:  1982-05

8.  Prophylactic antimetastatic treatment with aryldimethyltriazenes as adjuvants to surgical tumor removal in mice bearing Lewis lung carcinoma.

Authors:  G Sava; T Giraldi; C Nisi; G Bertoli
Journal:  Cancer Treat Rep       Date:  1982-01

9.  Percentage of cells in the S phase of the cell cycle in human lymphoma determined by flow cytometry.

Authors:  R C Braylan; L W Diamond; M L Powell; B Harty-Golder
Journal:  Cytometry       Date:  1980-11

10.  In vitro and in vivo selection of two Lewis lung carcinoma cell lines.

Authors:  A Sacchi; A Corsi; M Caputo; G Zupi
Journal:  Tumori       Date:  1979-12-31
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  5 in total

Review 1.  Perspectives in the treatment of cancer metastasis.

Authors:  S Garattini
Journal:  Clin Exp Metastasis       Date:  1987 Apr-Jun       Impact factor: 5.150

2.  Morphological analysis of metastatic potential and antimetastatic drug effects in mice bearing two lines of Lewis lung carcinoma.

Authors:  V Grill; F Mallardi; S Zorzet; L Perissin; T Giraldi
Journal:  Clin Exp Metastasis       Date:  1987-09       Impact factor: 5.150

3.  Effects of rotational stress on the effectiveness of cyclophosphamide and razoxane in mice bearing Lewis lung carcinoma.

Authors:  L Perissin; S Zorzet; P Piccini; V Rapozzi; T Giraldi
Journal:  Clin Exp Metastasis       Date:  1991 Nov-Dec       Impact factor: 5.150

4.  Effects of antimetastatic, antiinvasive and cytotoxic agents on the growth and spread of transplantable leukemias in mice.

Authors:  G Sava; T Giraldi; L Perissin; S Zorzet; G Decorti
Journal:  Clin Exp Metastasis       Date:  1987 Jan-Mar       Impact factor: 5.150

5.  Effects of prolonged treatment with decarbazine on tumor metastatic potential in mice bearing Lewis lung carcinoma.

Authors:  S Zorzet; L Perissin; V Rapozzi; S Pacor; T Giraldi
Journal:  Clin Exp Metastasis       Date:  1995-03       Impact factor: 5.150
  5 in total

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