| Literature DB >> 6539848 |
R E Boehme, T L Baker, I N Mefford, J D Barchas, W C Dement, R D Ciaranello.
Abstract
An inbred colony of narcoleptic doberman pinschers has been analyzed for muscarinic receptor levels in 19 discrete brain regions. In comparison to age-matched controls, receptors were generally elevated in the brainstem and reduced in forebrain areas. No changes in receptor binding affinity were detected. The increased receptor levels found in the brainstem suggest that cholinoceptive neurons in this region are hypersensitive and may be involved in the initiation of cataplexy and other aspects of the narcolepsy syndrome.Entities:
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Year: 1984 PMID： 6539848 DOI： 10.1016/0024-3205(84)90675-1
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037