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Literature DB >> 26600100

The Neurobiology of Sleep and Wakefulness.

Abstract

Cortical electroencephalographic activity arises from corticothalamocortical interactions, modulated by wake-promoting monoaminergic and cholinergic input. These wake-promoting systems are regulated by hypothalamic hypocretin/orexins, while GABAergic sleep-promoting nuclei are found in the preoptic area, brainstem and lateral hypothalamus. Although pontine acetylcholine is critical for REM sleep, hypothalamic melanin-concentrating hormone/GABAergic cells may "gate" REM sleep. Daily sleep-wake rhythms arise from interactions between a hypothalamic circadian pacemaker and a sleep homeostat whose anatomical locus has yet to be conclusively defined. Control of sleep and wakefulness involves multiple systems, each of which presents vulnerability to sleep/wake dysfunction that may predispose to physical and/or neuropsychiatric disorders.

Entities: Chemical Disease Gene Species

Keywords: EEG; Homeostasis; Hypocretin; NREM sleep; Neurotransmitter; REM sleep; Slow wave activity; Synchronization

Mesh：

Substances：

Year: 2015 PMID： 26600100 PMCID： PMC4660253 DOI： 10.1016/j.psc.2015.07.002

Source DB: PubMed Journal: Psychiatr Clin North Am ISSN： 0193-953X

332 in total

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38 in total

1. Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

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2. The Insomnia Plague in Fictional Macondo.

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Authors: Stephen V Faraone
Journal: Neurosci Biobehav Rev Date: 2018-02-08 Impact factor: 8.989

4. Whole-Brain Mapping of Direct Inputs to and Axonal Projections from GABAergic Neurons in the Parafacial Zone.

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Authors: Bo Zhang; Dongjun Guo; Lirong Han; Nicholas Rensing; Akiko Satoh; Michael Wong
Journal: Neurobiol Dis Date: 2019-10-09 Impact factor: 5.996

6. Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats.

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Journal: Sleep Date: 2017-09-01 Impact factor: 5.849

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Authors: Sabra S Inslicht; Madhu N Rao; Anne Richards; Aoife O'Donovan; Carolyn J Gibson; Tierney Baum; Thomas J Metzler; Thomas C Neylan
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Journal: Sleep Date: 2020-10-13 Impact factor: 5.849

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