The role of digitalis in the future.

Cardiac glycosides exert an acute positive inotropic effect on the normal and failing heart. Recent evidence establishes that the positive inotropic effect is maintained over several months in many patients. The effectiveness of long-term treatment with cardiac glycosides in relieving symptoms is less certain; only a small subset of patients benefits. An effect on mortality is not established. The use of digoxin in the treatment of mild heart failure is questionable since the drug has serious side-effects and the efficacy in patients already taking diuretics has not been established. The use of glycosides in the treatment of severe chronic heart failure is being challenged because of the availability of powerful diuretics, new vasodilators and alternative positive inotropes.