Literature DB >> 6526880

Gas chromatography-mass spectrometry characteristics of methylated perfluoroacyl derivatives of cytosine and 5-methylcytosine.

G B Mohamed, A Nazareth, M J Hayes, R W Giese, P Vouros.   

Abstract

Pentafluorobenzoyl and heptafluorobutyryl derivatives of cytosine and pentafluorobenzoyl-5-methylcytosine have been examined by mass spectrometry following permethylation. Electron impact mass spectra were used to confirm the structures of the derivatives. The permethylated pentafluorobenzoyl derivatives of cytosine and 5-methylcytosine are sensitive for quantitative analysis by capillary gas chromatography-mass spectrometry. Under negative ion chemical ionization conditions 1 femtogram of each is detected.

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Year:  1984        PMID： 6526880     DOI： 10.1016/s0021-9673(01)97735-0

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

Review 1.  Estimation of exposure of man to substances reacting covalently with macromolecules.

Authors:  P B Farmer; H G Neumann; D Henschler
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

2.  Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.

Authors:  K W Turteltaub; J S Felton; B L Gledhill; J S Vogel; J R Southon; M W Caffee; R C Finkel; D E Nelson; I D Proctor; J C Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

3.  Development of fast atom bombardment mass spectral methods for the identification of carcinogen-nucleoside adducts.

Authors:  M S Bryant; J O Lay; M P Chiarelli
Journal:  J Am Soc Mass Spectrom       Date:  1992-05       Impact factor: 3.109

4.  Trace derivatization of cytosine with pentafluorobenzoyl chloride and dimethyl sulfate.

Authors:  D H Fisher; J Adams; R W Giese
Journal:  Environ Health Perspect       Date:  1985-10       Impact factor: 9.031
  4 in total

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