Literature DB >> 6526016

The mutant vasopressin gene from diabetes insipidus (Brattleboro) rats is transcribed but the message is not efficiently translated.

H Schmale, R Ivell, M Breindl, D Darmer, D Richter.   

Abstract

The vasopressin gene from normal and diabetes insipidus (Brattleboro) rats has been isolated and sequenced. Except for a single deletion of a G residue in region coding for the neurophysin carrier protein the approximately 2300 nucleotides of both genes are identical. Blot analysis of hypothalamic RNA as well as transfection and microinjection experiments indicate that the mutant gene is correctly transcribed and spliced, however the resulting mRNA is not efficiently translated.

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Year:  1984        PMID： 6526016      PMCID： PMC557850          DOI： 10.1002/j.1460-2075.1984.tb02291.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  11 in total

Review 1.  Polyprotein gene expression: generation of diversity of neuroendocrine peptides.

Authors:  J Douglass; O Civelli; E Herbert
Journal:  Annu Rev Biochem       Date:  1984       Impact factor: 23.643

2.  Structure and comparison of the oxytocin and vasopressin genes from rat.

Authors:  R Ivell; D Richter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

3.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

4.  Heredtary and idiopathic types of diabetes insipidus.

Authors:  J R Green; G C Buchan; E C Alvord; A G Swanson
Journal:  Brain       Date:  1967-09       Impact factor: 13.501

5.  Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.

Authors:  H Schmale; D Richter
Journal:  Nature       Date:  1984 Apr 19-25       Impact factor: 49.962

6.  In vivo studies on the incorporation of microinjected acidic proteins of the large ribosomal subunit from Escherichia coli and artermia salina into oocyte ribosomes from Xenopus laevis.

Authors:  H Kalthoff; D Richter
Journal:  Biochemistry       Date:  1979-09-18       Impact factor: 3.162

7.  Biosynthesis of vasopressin, oxytocin, and neurophysins: isolation and characterization of two common precursors (propressophysin and prooxyphysin).

Authors:  J T Russell; M J Brownstein; H Gainer
Journal:  Endocrinology       Date:  1980-12       Impact factor: 4.736

8.  Transcription of cloned Moloney murine leukemia proviral DNA injected into Xenopus laevis oocytes.

Authors:  M Breindl; H Kalthoff; R Jaenisch
Journal:  Nucleic Acids Res       Date:  1983-06-25       Impact factor: 16.971

9.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

10.  Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor.

Authors:  H Schmale; S Heinsohn; D Richter
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  16 in total

1.  Radioautographic study of glycoprotein synthesis and fate in the hypothalamo-neurohypophyseal system of vasopressin-deficient Brattleboro rats.

Authors:  A Haddad; G Pelletier
Journal:  Anat Embryol (Berl)       Date:  1987

Review 2.  The map of chromosome 20.

Authors:  N E Simpson
Journal:  J Med Genet       Date:  1988-12       Impact factor: 6.318

3.  Quantitative in situ hybridization to measure single-cell changes in vasopressin and oxytocin mRNA levels after osmotic stimulation.

Authors:  J T McCabe; M Kawata; Y Sano; D W Pfaff; R A Desharnais
Journal:  Cell Mol Neurobiol       Date:  1990-03       Impact factor: 5.046

4.  Immunocytochemical staining of supraoptic neurons from homozygous Brattleboro rats by use of antibodies against two domains of the mutated vasopressin precursor.

Authors:  B Krisch; P Nahke; D Richter
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

5.  The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA.

Authors:  M Jacob; H Gallinaro
Journal:  Nucleic Acids Res       Date:  1989-03-25       Impact factor: 16.971

Review 6.  Neuroendocrine gene expression in the hypothalamus: in situ hybridization histochemical studies.

Authors:  W S Young; R T Zoeller
Journal:  Cell Mol Neurobiol       Date:  1987-12       Impact factor: 5.046

Review 7.  Transgenic animals as models for human disease--report of an EC Study Group.

Authors:  R Lathe; J J Mullins
Journal:  Transgenic Res       Date:  1993-09       Impact factor: 2.788

8.  Differential subcellular mRNA targeting: deletion of a single nucleotide prevents the transport to axons but not to dendrites of rat hypothalamic magnocellular neurons.

Authors:  E Mohr; J F Morris; D Richter
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

9.  Dominant-negative diabetes insipidus and other endocrinopathies.

Authors:  John A Phillips
Journal:  J Clin Invest       Date:  2003-12       Impact factor: 14.808

10.  Mutant vasopressin precursor in the endoplasmic reticulum of the Brattleboro rat. Ultrastructural evidence from individual "vasopressin" cells localized with the light microscope by use of a new gold/silver method for immunostain enhancement.

Authors:  S E Guldenaar; B T Pickering
Journal:  Cell Tissue Res       Date:  1988-09       Impact factor: 5.249
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