| Literature DB >> 6522924 |
C H Nightingale, R Quintiliani, M N Dudley, P Gough, M Hickingbotham, N S Jordan, D Rose, M Toscani.
Abstract
The pharmacokinetics of cefonicid in the serum and tissues of patients undergoing open heart surgery, vaginal hysterectomy, and hip replacement was studied and compared with that of cefazolin and cefoxitin. Cefonicid achieved serum and tissue concentrations that were higher and more prolonged than those of cefazolin and cefoxitin. For cefonicid parallelism was observed between the serum and tissue concentration-time curves. Correlations of these properties to clinical efficacy were not attempted.Entities:
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Year: 1984 PMID： 6522924 DOI： 10.1093/clinids/6.supplement_4.s821
Source DB: PubMed Journal: Rev Infect Dis ISSN： 0162-0886