Literature DB >> 6521858

Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover.

B L Roth, T Nakaki, D M Chuang, E Costa.   

Abstract

The 5HT-mediated contraction of rat thoracic aorta is competitively blocked by the specific receptor antagonist 5HT2 ketanserin. In this tissue the addition of 5HT activated the turnover of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT2 recognition sites appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.

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Year:  1984        PMID： 6521858     DOI： 10.1016/0028-3908(84)90244-2

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  21 in total

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6.  Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.

Authors:  C Nocjar; K D Alex; A Sonneborn; A I Abbas; B L Roth; E A Pehek
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Authors:  Joshua D Hutcheson; Vincent Setola; Bryan L Roth; W David Merryman
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8.  Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.

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Review 9.  Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs.

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10.  Serotonin-induced decrease of intracellular Ca(2+) release in platelets of bulimic patients normalizes during treatment.

Authors:  Lars Wöckel; Florian Daniel Zepf; Sabrina Koch; Anikó-Eva Meyer-Keitel; Martin H Schmidt
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