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Literature DB >> 652054

Prostaglandin D2 (PGD2)--a potent coronary vasoconstrictor agent in the guinea pig isolated heart.

Abstract

The action of prostaglandin D2 (PGD2) on myocardial force of contraction (MFC) and coronary vascular resistance (CVR) was studied in the isovolumetrically perfused guinea pig heart at constant driving frequency (180 beats/min). PGD2 (2 . 10(-9) - 1 . 10(-6) M) produced a concentration-dependent increase in the CVR while the MFC remained unchanged. The ED50 (50% of maximum response) of the coronary vasomotor action amounted to 4.3 . 10(-8) M PGD2. The results give evidence for a potent coronary vasoconstrictor activity of PGD2.

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Year: 1978 PMID： 652054 DOI： 10.1007/BF00586598

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

8 in total

1. Prostaglandin endoperoxides IV. Effects on smooth muscle.

Authors: M Hamberg; P Hedqvist; K Strandberg; J Svensson; B Samuelsson
Journal: Life Sci Date: 1975-02-01 Impact factor: 5.037

2. Cardiovascular actions of prostaglandins D and E in the sheep: evidence for two distinct receptors.

Authors: R L Jones
Journal: Adv Prostaglandin Thromboxane Res Date: 1976

3. Prostaglandins and cardiac anaphylaxis.

Authors: R Levi; G Allan; J H Zavecz
Journal: Life Sci Date: 1976-06-01 Impact factor: 5.037

4. Actions of prostaglandin E2 on myocardial mechanics, coronary vascular resistance and oxygen consumption in the guinea-pig isolated heat preparation.

Authors: R Krebs; K Schror
Journal: Br J Pharmacol Date: 1975-11 Impact factor: 8.739

5. Prostaglandin, slow-reacting substance, and histamine release from anaphylactic guinea-pig hearts, and its pharmacological modification.

Authors: R Liebig; W Bernauer; B A Peskar
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

Review 6. The synthesis and function of prostaglandins in the heart.

Authors: P Needleman
Journal: Fed Proc Date: 1976-10

7. Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin.

Authors: K Schrör; S Moncada; F B Ubatuba; J R Vane
Journal: Eur J Pharmacol Date: 1978-01-01 Impact factor: 4.432

8. Prostaglandin A2 (PGA2) increases the coronary vascular resistance in the guinea-pig isolated heart preparation.

Authors: K Schrör; R Krebs
Journal: Experientia Date: 1977-03-15

8 in total

1. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

Authors: Nicole Sawyer; Elizabeth Cauchon; Anne Chateauneuf; Rani P G Cruz; Donald W Nicholson; Kathleen M Metters; Gary P O'Neill; Francois G Gervais
Journal: Br J Pharmacol Date: 2002-12 Impact factor: 8.739

2. IgE-mediated activation of human heart in vitro.

Authors: G Marone; M Triggiani; R Cirillo; A Giacummo; S Hammarström; M Condorelli
Journal: Agents Actions Date: 1986-04

3. Radioimmunological determination of prostaglandin D2 synthesis in human thrombocytes.

Authors: H Anhut; B A Peskar; W Wachter; B Gräbling; B M Peskar
Journal: Experientia Date: 1978-11-15

4. Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay.

Authors: H Anhut; B A Peskar; W Bernauer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1978-12 Impact factor: 3.000