Literature DB >> 6519120

Binding of cefalotin to human serum albumin.

M O Decroix, J C Chaumeil, B Flouvat.   

Abstract

Binding of cefalotin to human serum albumin was studied in vitro by equilibrium dialysis and the quantitative measurement of cefalotin was made by fluorimetric assay. The binding rate of cefalotin to human serum albumin found to be 61,1%. The determination of drug binding parameters showed a large number of binding sites (n = 9.36) and a moderate affinity (K = 3898 M-1).

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Year:  1984        PMID： 6519120     DOI： 10.1007/BF03189640

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  16 in total

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Authors:  C H Nightingale; D S Greene; R Quintiliani
Journal:  J Pharm Sci       Date:  1975-12       Impact factor: 3.534

2.  Serum binding, distribution and excretion of four penicillin analogues following intravenous injection in man.

Authors:  C M KUNIN
Journal:  Proc Soc Exp Biol Med       Date:  1961-06

Review 3.  [Antibiotics and protein binding].

Authors:  J P Tillement; L Chauvelot
Journal:  Therapie       Date:  1978 May-Jun       Impact factor: 2.070

4.  In vitro assessment of tobramycin, a new aminoglycoside with anti-Pseudomonas activity.

Authors:  A Molavi; M Barza; W Cole; H Berman; L Weinstein
Journal:  Chemotherapy       Date:  1973       Impact factor: 2.544

5.  Pharmacokinetics of cefazolin in normal and uremic subjects.

Authors:  P G Welling; W A Craig; A L Gordon; C M Kunin
Journal:  Clin Pharmacol Ther       Date:  1974-04       Impact factor: 6.875

6.  Pharmacokinetics of cefazolin compared with four other cephalosporins.

Authors:  W M Kirby; C Regamey
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

7.  Pharmacology of cefazolin and other cephalosporins in patients with renal insufficiency.

Authors:  W A Craig; P G Welling; T C Jackson; C M Kunin
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

8.  Binding of certain acidic drugs to human albumin: theoretical and practical estimation of fundamental parameters.

Authors:  J P Tillement; R Zini; P d' Athis; G Vassent
Journal:  Eur J Clin Pharmacol       Date:  1974-07-26       Impact factor: 2.953

9.  Rapid sensitive fluorometric analysis of cephalosporin antibiotics.

Authors:  A B Yu; C H Nightingale; D R Flanagan
Journal:  J Pharm Sci       Date:  1977-02       Impact factor: 3.534

10.  Bactericidal activity and pharmacology of cefazolin.

Authors:  M G Bergeron; J L Brusch; M Barza; L Weinstein
Journal:  Antimicrob Agents Chemother       Date:  1973-10       Impact factor: 5.191
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