Literature DB >> 6518276

The determination of flux through phenylalanine hydroxylase and homogentisate oxidase in isolated hepatocytes.

M J Fisher, C I Pogson.   

Abstract

The metabolic fate of [4-3H]phenylalanine incubated with isolated hepatocytes has been investigated. Analysis of 3H2O production and fluorimetric estimation of tyrosine production has allowed calculation of flux through phenylalanine hydroxylase and homogentisate oxidase. The resulting flux determinations are physiologically relevant and hormonally sensitive.

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Year:  1984        PMID： 6518276     DOI： 10.1007/bf01138165

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  3 in total

1.  The role of insulin in the modulation of glucagon-dependent control of phenylalanine hydroxylation in isolated liver cells.

Authors:  M J Fisher; A J Dickson; C I Pogson
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

2.  Phosphopeptide analysis of phenylalanine hydroxylase isolated from liver cells exposed to hormonal stimuli.

Authors:  M J Fisher; A J Dickson; C I Pogson
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

3.  The polyamine-dependent modulation of phenylalanine hydroxylase phosphorylation state and enzymic activity in isolated liver cells.

Authors:  M J Fisher; A J Dickson; C I Pogson
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857
  3 in total

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