Literature DB >> 3800881

The polyamine-dependent modulation of phenylalanine hydroxylase phosphorylation state and enzymic activity in isolated liver cells.

M J Fisher, A J Dickson, C I Pogson.   

Abstract

The role of polyamines in the control of phenylalanine hydroxylase phosphorylation state and enzymic activity was investigated. Pre-treatment of liver cells with spermine (1 mM) abolishes the glucagon (1 nM)-stimulated increase in hydroxylase phosphorylation. Concurrently there is a decrease in phenylalanine hydroxylation flux, reflecting decreased enzyme activity; 50% inhibition occurs at approx. 10 microM-spermine. These results are discussed in the context of reports concerning the properties of protein phosphatase 2A.

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Year:  1986        PMID： 3800881      PMCID： PMC1146977          DOI： 10.1042/bj2370277

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  The protein phosphatases involved in cellular regulation. Glycolysis, gluconeogenesis and aromatic amino acid breakdown in rat liver.

Authors:  S Pelech; P Cohen; M J Fisher; C I Pogson; M R El-Maghrabi; S J Pilkis
Journal:  Eur J Biochem       Date:  1984-11-15

Review 2.  Polyamines.

Authors:  C W Tabor; H Tabor
Journal:  Annu Rev Biochem       Date:  1984       Impact factor: 23.643

3.  The protein phosphatases involved in cellular regulation. Influence of polyamines on the activities of protein phosphatase-1 and protein phosphatase-2A.

Authors:  H Y Tung; S Pelech; M J Fisher; C I Pogson; P Cohen
Journal:  Eur J Biochem       Date:  1985-06-03

4.  Effects of adrenergic agents, vasopressin and ionophore A23187, on the phosphorylation of, and flux through, phenylalanine hydroxylase in rat liver cells.

Authors:  M J Fisher; M A Santana; C I Pogson
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857

5.  Some aspects of the phosphorylation of phenylalanine 4-monooxygenase by a calcium-dependent and calmodulin-dependent protein kinase.

Authors:  A P Døskeland; C M Schworer; S O Døskeland; T D Chrisman; T R Soderling; J D Corbin; T Flatmark
Journal:  Eur J Biochem       Date:  1984-11-15

6.  Regulation of protein phosphorylation by polyamines in hepatocytes.

Authors:  P Auberger; M Samson; G Le Cam; A Le Cam
Journal:  Biochim Biophys Acta       Date:  1984-10-16

7.  Stimulation of pyruvate dehydrogenase phosphatase activity by polyamines.

Authors:  Z Damuni; J S Humphreys; L J Reed
Journal:  Biochem Biophys Res Commun       Date:  1984-10-15       Impact factor: 3.575

8.  Inhibition of hormonal induction of tyrosine aminotransferase by polyamines in freshly isolated rat hepatocytes.

Authors:  P Auberger; M Samson; A Le Cam
Journal:  Biochem J       Date:  1983-09-15       Impact factor: 3.857

9.  The determination of flux through phenylalanine hydroxylase and homogentisate oxidase in isolated hepatocytes.

Authors:  M J Fisher; C I Pogson
Journal:  Biosci Rep       Date:  1984-10       Impact factor: 3.840

10.  The short term hormonal control of cytoplasmic protein phosphorylation in hepatocytes from fed rats.

Authors:  R G Knowles; D A Hems
Journal:  Int J Biochem       Date:  1983
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  2 in total

1.  The role of insulin in the modulation of glucagon-dependent control of phenylalanine hydroxylation in isolated liver cells.

Authors:  M J Fisher; A J Dickson; C I Pogson
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

2.  Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin.

Authors:  A P Thomas; T A Diggle; R M Denton
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857
  2 in total

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