| Literature DB >> 6511708 |
T Trnovec, S Bezek, Z Kállay, M Durisová, J Navarová.
Abstract
The dose dependence of gentamicin renal uptake in guinea-pigs was studied. The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3-48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level.Entities:
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Year: 1984 PMID： 6511708 DOI： 10.1093/jac/14.5.543
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790