Literature DB >> 6508810

Thermodynamics of reverse electron transfer across site 1: ATP/2e- is greater than one.

J A Freedman, J J Lemasters.   

Abstract

ATP-driven, rotenone-sensitive, reverse electron transfer from succinate to acetoacetate was measured in rat liver mitochondria in the presence of cyanide. In the approach to equilibrium, the absolute ratio of the free energy change of electron transfer to that of ATP hydrolysis exceeded 1, tending towards about 1 1/4. The data support an H+/2e- stoichiometry of 5 for Site 1 as predicted by a thirteen-proton model of chemiosmotic coupling.

Entities:  

Mesh:

Substances:

Year:  1984        PMID: 6508810     DOI: 10.1016/s0006-291x(84)80325-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  3 in total

1.  Proton/electron stoichiometry of mitochondrial complex I estimated from the equilibrium thermodynamic force ratio.

Authors:  G C Brown; M D Brand
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

2.  Sensitivity to NN'-dicyclohexylcarbodi-imide of proton translocation by mitochondrial NADH:ubiquinone oxidoreductase.

Authors:  P J Honkakoski; I E Hassinen
Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857

3.  Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation.

Authors:  Seonmin Lee; Eunyoung Tak; Jisun Lee; M A Rashid; Michael P Murphy; Joohun Ha; Sung Soo Kim
Journal:  Cell Res       Date:  2011-03-29       Impact factor: 25.617

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.