Literature DB >> 3026336

Sensitivity to NN'-dicyclohexylcarbodi-imide of proton translocation by mitochondrial NADH:ubiquinone oxidoreductase.

P J Honkakoski, I E Hassinen.   

Abstract

Proton extrusion during ferricyanide reduction by NADH-generating substrates or succinate was studied in isolated rat liver mitochondria with the use of optical indicators. NN'-Dicyclohexylcarbodi-imide (DCCD) caused a decrease of 84% in the H+/e- ratio of NADH:cytochrome c reduction, but a decrease of only 49% in that of succinate:cytochrome c reduction, even though electron transfer was decreased equally in both spans. The data indicate that a DCCD-sensitive channel operates in the NADH:ubiquinone oxidoreductase region of the respiratory chain.

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Year:  1986        PMID： 3026336      PMCID： PMC1147078          DOI： 10.1042/bj2370927

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  28 in total

Review 1.  Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms.

Authors:  P Mitchell; R Mitchell; A J Moody; I C West; H Baum; J M Wrigglesworth
Journal:  FEBS Lett       Date:  1985-08-19       Impact factor: 4.124

2.  Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex.

Authors:  M D Brand; M K Al-Shawi; G C Brown; B D Price
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

3.  Isolation and amino acid sequence of the 8 kDa DCCD-binding protein of beef heart ubiquinol:cytochrome c reductase.

Authors:  U Borchart; W Machleidt; H Schägger; T A Link; G von Jagow
Journal:  FEBS Lett       Date:  1985-10-21       Impact factor: 4.124

4.  Oxidoreduction of cytochrome b in the presence of antimycin.

Authors:  M K Wikström; J A Berden
Journal:  Biochim Biophys Acta       Date:  1972-12-14

5.  The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.

Authors:  D G Nicholls
Journal:  Eur J Biochem       Date:  1974-12-16

Review 6.  The mitochondrial electron transport and oxidative phosphorylation system.

Authors:  Y Hatefi
Journal:  Annu Rev Biochem       Date:  1985       Impact factor: 23.643

Review 7.  The effect of N,N'-dicyclohexylcarbodiimide on enzymes of bioenergetic relevance.

Authors:  A Azzi; R P Casey; M J Nałecz
Journal:  Biochim Biophys Acta       Date:  1984-12-17

8.  The H+/O ratio of proton translocation linked to the oxidation of succinate by mitochondria.

Authors:  K Krab; J Soos; M Wikström
Journal:  FEBS Lett       Date:  1984-12-10       Impact factor: 4.124

9.  Dicyclohexylcarbodiimide binds to cytochrome b and subunit VIII in soluble complex III from beef heart mitochondria.

Authors:  L Clejan; C G Bosch; D S Beattie
Journal:  J Biol Chem       Date:  1984-09-25       Impact factor: 5.157

10.  Proton translocation coupled to quinone reduction by reduced nicotinamide--adenine dinucleotide in rat liver and ox heart mitochondria.

Authors:  H G Lawford; P B Garland
Journal:  Biochem J       Date:  1972-12       Impact factor: 3.857
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  3 in total

1.  Effects of Helminthosporium maydis Race T Toxin on Electron Transport in Susceptible Corn Mitochondria and Prevention of Toxin Actions by Dicyclohexylcarbodiimide.

Authors:  M J Holden; H Sze
Journal:  Plant Physiol       Date:  1989-12       Impact factor: 8.340

2.  The distribution of electron flow in the branched respiratory chain of Micrococcus luteus.

Authors:  D N Ostrovsky
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

3.  NN'-dicyclohexylcarbodi-imide-sensitivity of bovine heart mitochondrial NADH: ubiquinone oxidoreductase. Inhibition of activity and binding to subunits.

Authors:  P T Vuokila; I E Hassinen
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857
  3 in total

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